Renal Cell Carcinoma Flashcards
1
Q
Hemartoma comprised of Blood vessels ,sMOOTH MUSCLE ,adipose tissue ?
A
AngioMyolipoma
2
Q
Maliganant epithelial tumor from kidney tubules ——-
A
Renal cell Ca
2
Q
Angiomyolipoma inc risk of ———
A
Tubeerous sclerosis
133-pathoma
3
Q
Classical triad of Renal Cell Ca ?
A
- Hematuria=Most common
- Flank pain
- Palpable mass
4
Q
Features of Renal cell Ca ?
A
- Fever
- Weight loss
- Paraneoplastic syndrome
- EPO
- Renin
- PTHrP
- ACTH
5
Q
Rare association of RCCa ?
A
Left sided varicocele
6
Q
Varococele process ?
A
Left renal vein—–Left spermatic vein —- Varicocele
7
Q
Why right sided varicocele is not seen ?
A
Right spermatic vein drains directly into the IVC
134=Pathoma
8
Q
Gross exam result in RCCa ?
A
Yellow mass
9
Q
Microscopic result in RCCa ?
A
Clear cytoplasm=Clearn cell type
10
Q
Pathogenesis which gene ?
A
VHL-3p
Tumor suppressor gene
11
Q
VHL-3p fate >?
A
- inc IGF-1 = Promotes growth
- inc HIF transcription factor = inc PDGF & VEGF
12
Q
Tumor type in RCC a?
A
- Sporadic
- Hereditary
13
Q
Sporadic tumor in RCCa ?
A
- Adult
- Upper pole of kidney
- Cigarette smoke risk
14
Q
Hereditary tumor of RCCa ?
A
Younger
Bilateral
