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USMLE-Pathology-(Pathoma+ FA+UWorld) > Non Hodgkin Lymphoma > Flashcards

Non Hodgkin Lymphoma Flashcards

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USMLE® Step 1 flashcards
1
Q

Follicular lymphoma ?

A

Neoplastic proliferation of small B cell CD20+

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2
Q

Presentation of Follicular L ?

A

Adult + Painless Lymphadenopathy

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2
Q

Follicular L Histo ?

A

Follicle like nodules

Pathoma-61

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3
Q

Mutation in Chromosomes?

A

Chromosomes 18 = BCL2 translocate In Chromosome 14 = Ig heavy chain

BCL2 = inhibit Apoptosis

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3
Q

Tx of Follicular L ?

A

Rituximiab
AntiCD20+ antibody

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4
Q

Progression of Follicular L ?

A

Diffuse Large B cell Lymphoma

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4
Q

Follicular Lymphoma B cell marker ?

A

CD20+

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5
Q

Follicualr L vs Reactive Follicular Hyperplasia ?

A
  1. Normal lymph node architecture disruption
  2. BCL2 expression
  3. Monoclonality
  4. No Tingible Body Macrophage

Opposite in R Follicular Hyperplasia

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6
Q

Mantle L

Same as Follicular Lymphoma

A
  1. Neoplastic proliferation of B cells CD20+ that expands Mantle Zone
  2. Painless Lymphedenopathy
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7
Q

Mutation in Mantle Cell L ?

A

t ( 11 -14 )

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8
Q

Chromosome translocation in Mantle cell L ?

A

t (11-14)
Chr-11= Cyclin D1
Chr - 14 = Ig heavy chain locus

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9
Q

Marginal Zone L?

A

Neoplastic proliferation of small B cells CD20+

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10
Q

Marginal zone L in mucosal sites ?

A

MALToma

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11
Q

MALToma Tx ?

A

H Pylori

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12
Q

Assocciation of Marginal Zone Lymphoma?

A
  1. Hashimoto thyroiditis
  2. Sjogren syndrome
  3. H pylori Gastritis
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13
Q

Burkitt Lymphoma ?

same shit <,,,,,,,,,,,,

A

Same as above
but now EPV

14
Q

Presentation in Burkitt Lymphoma ?

A

Extranodal mass in a child or young adult

15
Q

Chromosome translocation in Burkitt lymphoma ?

A

t- (8-14)
CHR - 8 -c-myc
CHR - 14 - Ig heavy chain locus

16
Q

Histo of burkitt lymphoma ?

A

Starry sky appearance

62

17
Q

Most common NHL ?

A

Diffuse Large B cell kymphoma

18
Q

Arise from –

A

Follicular lymphoma

19
Q

Clinically aggressive NHL ?

A

Diffuse Large b CELL L

PATHOMA-62

USMLE-Pathology-(Pathoma+ FA+UWorld) (75 decks)

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