Non Hodgkin Lymphoma Flashcards
Follicular lymphoma ?
Neoplastic proliferation of small B cell CD20+
Presentation of Follicular L ?
Adult + Painless Lymphadenopathy
Follicular L Histo ?
Follicle like nodules
Pathoma-61
Mutation in Chromosomes?
Chromosomes 18 = BCL2 translocate In Chromosome 14 = Ig heavy chain
BCL2 = inhibit Apoptosis
Tx of Follicular L ?
Rituximiab
AntiCD20+ antibody
Progression of Follicular L ?
Diffuse Large B cell Lymphoma
Follicular Lymphoma B cell marker ?
CD20+
Follicualr L vs Reactive Follicular Hyperplasia ?
- Normal lymph node architecture disruption
- BCL2 expression
- Monoclonality
- No Tingible Body Macrophage
Opposite in R Follicular Hyperplasia
Mantle L
Same as Follicular Lymphoma
- Neoplastic proliferation of B cells CD20+ that expands Mantle Zone
- Painless Lymphedenopathy
Mutation in Mantle Cell L ?
t ( 11 -14 )
Chromosome translocation in Mantle cell L ?
t (11-14)
Chr-11= Cyclin D1
Chr - 14 = Ig heavy chain locus
Marginal Zone L?
Neoplastic proliferation of small B cells CD20+
Marginal zone L in mucosal sites ?
MALToma
MALToma Tx ?
H Pylori
Assocciation of Marginal Zone Lymphoma?
- Hashimoto thyroiditis
- Sjogren syndrome
- H pylori Gastritis
Burkitt Lymphoma ?
same shit <,,,,,,,,,,,,
Same as above
but now EPV
Presentation in Burkitt Lymphoma ?
Extranodal mass in a child or young adult
Chromosome translocation in Burkitt lymphoma ?
t- (8-14)
CHR - 8 -c-myc
CHR - 14 - Ig heavy chain locus
Histo of burkitt lymphoma ?
Starry sky appearance
62
Most common NHL ?
Diffuse Large B cell kymphoma
Arise from –
Follicular lymphoma
Clinically aggressive NHL ?
Diffuse Large b CELL L
PATHOMA-62
