Nephritic Syndrome Flashcards
1
Q
Features of Nephritic syndrome ?
A
- Glomerular inflammation ‘
- Bleeding
- Proteinuria <3.5g/day
- Salt retention
- OLiguria
- Azotemia
- Urine-RBC cast & Dysmorphic RBC
- HTN
- Periorbital edema
2
Q
Biopsy of nephritic syndrome ?
A
- Hypercellular
- Inflammed glomeruli
3
Q
Damage process in nephritic syndrome ?
A
Immune co plex mediated activation of complex C5a - that attacts neutrophils - Damage
Pathoma-130
3
Q
PSGN features ?
A
- Hematuria-Coca cola urine
- Oliguria
- HTN
- Periorbital edema
3
Q
Post streptococcal glomerulonephritis
PSGN ?
A
Group-A Beta hemolytic streptococcal infection
4
Q
PSGN site ?
A
- Skin - Impetigo
- Pharynx
5
Q
IF result in PSGN ?
A
+
Subepithelial HUMP on EM
5
Q
Tx of PSGN ?
A
Supportive
6
Q
H & E result in PSGN ?
A
Hypercellular
Inflammed glomeruli
7
Q
Progresion of PSGN ?
A
- Adult = Rapidly Progressive Glomerulonephritis
- Child = renal F
8
Q
Rapidly Progressive Glomerulonephritis ?
A
It progress to Renal F in weeks to months
9
Q
H & E stain in RPGN ?
A
Crescents in bowman space of glomeruli
Crescent= Fibrin + Macrophage
10
Q
IF = Granular ?
A
PSGN /
Diffuse Proliferative Glomerulonephritis
11
Q
IF = Linear ?
A
Goodposture syndrome
12
Q
Negative = IF - Pauci Immune
A
- Wegener granulomatosis
- Microscopic polyangitis
- Churg-Strauss syndrome
