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USMLE-Pathology-(Pathoma+ FA+UWorld) > Nephritic Syndrome > Flashcards

Nephritic Syndrome Flashcards

1
Q

Features of Nephritic syndrome ?

A
  1. Glomerular inflammation ‘
  2. Bleeding
  3. Proteinuria <3.5g/day
  4. Salt retention
  5. OLiguria
  6. Azotemia
  7. Urine-RBC cast & Dysmorphic RBC
  8. HTN
  9. Periorbital edema
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2
Q

Biopsy of nephritic syndrome ?

A
  1. Hypercellular
  2. Inflammed glomeruli
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3
Q

Damage process in nephritic syndrome ?

A

Immune co plex mediated activation of complex C5a - that attacts neutrophils - Damage

Pathoma-130

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3
Q

PSGN features ?

A
  1. Hematuria-Coca cola urine
  2. Oliguria
  3. HTN
  4. Periorbital edema
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3
Q

Post streptococcal glomerulonephritis
PSGN ?

A

Group-A Beta hemolytic streptococcal infection

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4
Q

PSGN site ?

A
  1. Skin - Impetigo
  2. Pharynx
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5
Q

IF result in PSGN ?

A

+
Subepithelial HUMP on EM

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5
Q

Tx of PSGN ?

A

Supportive

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6
Q

H & E result in PSGN ?

A

Hypercellular
Inflammed glomeruli

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7
Q

Progresion of PSGN ?

A
  1. Adult = Rapidly Progressive Glomerulonephritis
  2. Child = renal F
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8
Q

Rapidly Progressive Glomerulonephritis ?

A

It progress to Renal F in weeks to months

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9
Q

H & E stain in RPGN ?

A

Crescents in bowman space of glomeruli

Crescent= Fibrin + Macrophage

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10
Q

IF = Granular ?

A

PSGN /
Diffuse Proliferative Glomerulonephritis

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11
Q

IF = Linear ?

A

Goodposture syndrome

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12
Q

Negative = IF - Pauci Immune

A
  1. Wegener granulomatosis
  2. Microscopic polyangitis
  3. Churg-Strauss syndrome
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13
Q

c-ANCA association ?

A
  1. Wegener granulomatosis
14
Q

p-ANCA association ?

A
  1. Microscopic polyangitis
  2. Churg-Strauss syndrome

130

15
Q

PSGN / diffuse ProL GN which disease ?

16
Q

Goodposture syndrome manifestation ?

A
  1. Anti basement membrane AB
  2. Hematuria
  3. Hemoptysis
16
Q

IgA nephropathy Other name ?

A

Berger disease

17
Q

IF result in BERGER D ?

A

IgA immune complex deposition in mesangium

pathoma-131

17
Q

IgA nephropathy manifestation ?

A
  1. inc IgA production
  2. Urine - RBC cast
  3. Gastroenteritis
  4. Hematuria
18
Q

Alport syndrome cause ?

A

Inherited defect in Type-4 collagen

X-linked

18
Q

AS features >

A
  1. Hematuria
  2. Sensory hearing loss
  3. Ocular disturbance
19
Q

Churg strauss VS Microscopic polyangitis ?

as both p-ANCA

A
  1. Asthma
  2. Eosinophilia
  3. Granulomatous inflammation

130

20
Q

Progression of IgA nephropathy >?

USMLE-Pathology-(Pathoma+ FA+UWorld) (75 decks)

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