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USMLE-Pathology-(Pathoma+ FA+UWorld) > Cervix Pathology Female Genitial > Flashcards

Cervix Pathology Female Genitial Flashcards

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USMLE® Step 1 flashcards
1
Q

Parts of cervix ?

A
  1. Exocervix
  2. Endocervix

Pathoma-139

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2
Q

Cervix lining epithelium ?

A
  1. Exocervix=Non-Keratizing Squamous Epithelium
  2. EndoCervix = Columnar cells
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3
Q

Junction between endo & exocervix is called ?

A

Transformation zone

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4
Q

Low risk HPV ?

A

HPV- 6 11

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4
Q

Cervix in the transformation zone is infected by ——

A

HPV

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4
Q

High risk HPV ?

A

HPV- 16 18 31 33

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5
Q

Infection by HPV is eradicated by >?

A

Acute inflammation

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6
Q

Infection in HPV results in —–?

A

Cervical Intraepithelial Neoplasia=CIN

Cervical Dysplasia

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7
Q

High risk HPV produce which protein ?

A

E6
E7

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8
Q

Result of E6 E7 ?

A

E6 = destruction p53 = loss of tumor suppressor protein
E7 = DESTRUCTION Rb = loss of tumor suppressor protein

139

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9
Q

Cervial Intraepitheelial Neoplasia characteristics?

A
  1. Koilocytic changes
  2. Disordered cellular maturation
  3. Nuclear atypia
  4. Inc mitotic activity

Pathoma-140

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10
Q

CIN grading ?

A
  1. CIN- I = <1/3 OF THE THICKNESS OF TH EEPITHELIUM
  2. CIN- II = <2/3
  3. CIN- III = entire thickness
  4. Carcinoma In Situ = Involve entire thickness of the epithelium
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11
Q

Carcinoma in situ fate ?

A

Invasive squamous cell Ca

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12
Q

Invasive carcinoma that arises from the cervical epithelium is called ?

A

Cervical Ca

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13
Q

Presentation of cervical carcinoma ?

A
  1. Vaginal bleeding
  2. Postcoital bleeding
  3. Cervical discharge
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14
Q

Death in cervical Ca common cause >?

A
  1. Hydronephrosis
  2. Postrenal f
14
Q

Key risk factor for Cervical Ca ?

A
  1. Smoke
  2. AIDS
  3. HPV infection = MUST
14
Q

Subtypes of Cervical Ca ?

A
  1. Squamous cell Ca
  2. Adenocarcinoma
15
Q

If PAP is abnormal then next step ?

A
  1. Colposcopy
  2. Biopsy
15
Q

Screening for Cervical Ca ?

A

PAP smear

16
Q

High grade dysplasia characteristics in PAP smear ?

A
  1. Hyperchromatic dark nuclei
  2. High Nuclear to cytoplasmic ratio
17
Q

Immunization of cervical carcinoma ?

A

Preventing HPV INFECTION

141 PATHOMA

18
Q

Quadrivalent vaccine ?

A

HPV-6 11 16 18

19
Q

AB against 6 11 ?

A

Condyloma

20
Q

AB AGAINST 16 1 8?

A

CIN
Carcinoma

USMLE-Pathology-(Pathoma+ FA+UWorld) (75 decks)

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