Multiple Myeloma Flashcards
1
Q
Multiple myeloma ?
A
Maliganant proliferation of plasma cells in bone marrow
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2
Q
Most common primary maliganancy of bones ?
A
Multiple myeloma
3
Q
MM which serum is high ?
A
IL-6
4
Q
MM stimulate production of what ?
A
- Plasma cell growth
- Ig production
5
Q
Clinical features OF MM ?
A
- Bone pain + Hypercalcemia
- Neoplastic plasma cell = Activate RANK receptor of osteoclasts
- X-ray = Punched out skeletal lesion
- Risk of FRACTURE
- inc serum protein
- M spike present in SERUM PROTEIN ELECTROPHORESIS SPEP
- Common Ig === IgM IgA
- Risk of infection
- RBC=Rouleaux formation
- Dec charge between RBC
- Primary AL amyloidosis
- Proteinuria
- Free light chain in urine as Bence Jones Protein
- Renal F = Myeloma kidney
6
Q
Rank receptor ?
A
Osteoclast
MM
