Lung Cancer

Question 1

Risk factor for Lung Ca ??

Answer 1

1. Cigarette - Polycyclic aromatic hydrocarbons
2. Arsenic
3. Radon - Radioactive decay of uranium
4. Asbestos
5. Coal fueled stoves
6. Metals - Ar Cr Ni

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Question 2

Clinical features of LCa ??

Answer 2

1. Cough
2. Hemoptysis
3. Dyspnea
4. Weight loss
5. Post obstructive P

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Question 2

Imaging result of Lung Ca ?

Answer 2

1. Large
2. Spiculated mass

Question 3

CXR in Lung Ca ??

Answer 3

Solitary nodule
Coin lesion

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Question 4

Benign lesion granuloma ??

Answer 4

TB/Fungus
Histoplasma

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Question 5

Small Cell Ca location ??

Answer 5

Central

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Question 5

Bronchial hemartoma ??

Answer 5

Lung tissue + cartilage
=Often calcified on imaging

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Question 6

Only peripheral Ca ????/

Answer 6

Adenocarcinoma

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Question 7

Chromogranin + which Ca ??

Answer 7

1. Small cell Ca
2. Carcinoid tumor

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Question 8

Poorly differentiated Ca ??

Answer 8

1. Small cell Ca
2. Large cell neuroendocrine carcinoma

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Question 9

Metastasis to lung location / Feature ??

Answer 9

Multiple canon ball nodules on imaging

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Question 10

Adenocarcinoma IHC expression ??

ImmunoHistoChemistry

Answer 10

TTF-1 expression in IF

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Question 11

Most common type of carcinoma in non-smoker and female ??

Answer 11

Adenocarcinoma

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Question 12

ImmunoHistoChemistry result in squamous cell Ca ??

Answer 12

1. Keratin pearls
2. Intercellular bridge
3. p40

Question 14

P like consolidation in which Ca ?/

Answer 14

adenocarcinoma

Question 15

PTHrP maybe produced by —-

Answer 15

Squamous cell Ca

Question 16

Polyp like bronchus in which Ca ??

Answer 16

Carcinoid Ca

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Question 17

Adenocarcinoma characteristics histopathologically —-

UWorld

Answer 17

1. Invasive glandular cells
2. Abundant cytoplasm
3. Nuclei=Eccentrically placed

Question 18

Imaging result of adenocarcinoma ?

Answer 18

A discrete mass or pneumonia like consolidation at the periphery of the lung

UWorld

Question 19

Nonsmoker cause of adenocarcinoma ?

UW

Answer 19

1. Epidermal Growth Factor Receptor-EGFR mutations
2. ALK gene rearrangement

UW

Question 20

Association of adenocarcinoma ?

UWorld

Answer 20

1.Clubbing
2.Hypertrophic osteoarthropathy

UWorld

Question 21

Tumors present in the lung apex (superior sulcus ) are called ?

UW

Answer 21

Pancoast tumor

UW

Question 22

Invasion of sorrounding structures near the apex of the lung results —

UW

Answer 22

1. Ipsilateral horner syndrome
2. Rib destruction
3. Atrophy of hand muscles
4. Pain in the distribution of C8 T1 T2 nerve roots

UWorld

Question 23

Histopathology result of small cell ca ?

UW

Answer 23

1. Small round / oval cells
2. Scant cytoplasm
3. Hyperchromatic blue nuclei
4. Granular chromatin

UW

Question 23

Small cell Ca present in whom ?

UW

Answer 23

Smoker + Centrally placed

UW

Question 24

Immunohistochemical result of small cell Ca ?

UW

Answer 24

+ for neeuroendocrine marker

Question 25

Neuroendocrine marker name ?

Neuroendocrine marker + for small cell Ca

UWorld

Answer 25

1. Chromogranin
2. Synaptophysin
3. Neural cell adhesion molecule CD56

UW

Question 26

Association of small cell Ca ?

UW

Answer 26

Paraneoplastic syndrome
-SIADH
-Cushing syndrome

Question 27

SIADH in small cell Ca ??

UW

Answer 27

Ectopic secretion of antidiuretic hormone

UW

Question 28

Characteristics of Syndrome Of Inappropriate AntiDiuretic Hormone SIADH ?

UW

Answer 28

Hyponatremia
dec Serum ormolarity
urine osmolarity >100mOsm/kg

UWorld