Cardiomyopathy Flashcards
All 4 chambers of the heart dilation is called—
Dilated cardiomyopathy
Dilated cardiomyopathy results in —-
- Systolic dysfunction
- Biventriculat CHF
- Mitral v regurgitation
- Tricuspid v regurgitation
- Arrhythmia
Massive hypertrophy of the LV ?
Hypertrophic cardiomyopathy
Tx of dilated cardiomyopathy ?
Heart transplant
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Causes of dilated cardiomyopathy –
- Autosomal dominant
- Alchohol
- Drugs - Doxurubicin
- Late preganancy
- Hemochromatosis
- Myocarditis - Coxsackie A & B
- Chest pain , HF , Arrhythmia
Biopsy result of hypertrophic cardiomyopathy –
Myofiber hypertrophy + Disarray
Cause of hypertrophic cardiomyopathy ?
Mutation - Sarcomere protein
Clinical features of hypertrophic cardiomyopathy ??
- dec Cardiac Output
- LV hypertrophy
- Sudden death - Veentricular arrhythmias
- Syncope with exercise
Subaortic hypertrophy of the ventricular septum results in —-
Aortic stenosis
EKG changes in Restrictive cardiomyopathy ?
- Low voltage EKG
- Diminished QRS complex
Causes of RC ?
- Amyloidosis
- Sarcoidosis
- Endocardial fibroelastosis
- Loeffler syndrome
dec Compliance of the ventricular endomyocardium that restricts filling during diastole ——————
Restricive cardiomyopathy
Loeffler syndorme meaning?
Endomyocardial fibrosis + Eosinophilic infiltrate + Eosinophilia
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Which gene mutation in dilated Cardiomyopathy?
TTN gene in sacromeric protein titin
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Findings of dilated cardiomyopathy ?
- HF
- S3
- Systolic regurgitant murmur
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CXR findings of DC ?
Ballon appearance
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Echocardiogram result of DC ?
Dilated heart
Which type of hypertrophy in DC ?
Eccentric
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Tx of DC ?
- Heart transplant
- Na+ restriction
- ACEi
- ARB
- Beta blocker
- Spironolactone
- ICD
- Diuretics
- Sacubitril
Stress cardiomyopathy why ?
inc sympathetic stimulation
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Stress cardiomyopathy other name ?
- Tokotsubo Cardiomyopathy
- Broken heart syndrome
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Eccentric hypertrophy feature ?
LV RV enlarge
inc SV inc CO
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Histo of HC ?
Sacromere in parallel
Concentric hypertrophy
Mutation in Hypertrophic cardiomyopathy ?
myosin binding protein C & beta myosin heavy chain
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Tx of HC ??
- Beta blocker
- CCB-Verapamil
- ICD-if high risk
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Which drug should be avoid in HC ?
- Diuretics
- Vasodilator
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Hypertrophic obstructive Cardiomyopathy means—
LV outflow tract obstructed
=asymmetric septal hypertrophy
=systolic ant motion of mitral valve
=outflow obstruction
=dyspnea - syncope
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Findings in Hypertrophic Cardiomyopathy?
- S4
- Systolic murmur
Restrictive C casue ?
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P=Postradiation fibrosis
L=Loffler endocarditis
E=Endocardial fibroelastosis
A=Amyloidosis
S=Sarcoidosis
H=Hemochromatosis
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Endocardial fibroelastosis in which Cardiomyopathy?
Restrictive C
Other cause of Concentric LV Hypertrophy ?
- Chronic HTN
- Friedreich ataxia
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