Infectious Mononucleosis IM

Question 1

IM caused by ?

Answer 1

EBV= Lymphocytic leukocytosis = Comprised of reactive CD8+ T cell

Question 2

Transmission of EBV ?

Answer 2

Saliva
=Kissing disease
Teenagers

Question 3

EBV effects ?

Answer 3

1. Oropharynx= Pharyngitis
2. Liver=Hepatitis = Hepatomegaly = Elevated Liver enzymes
3. B cells

Question 4

CD8+ Response in infectious mononucleosis ?

Answer 4

1. Generalized Lymphadenopathy - LAD- T cell hyperplasia = Lymph node paracortex
2. Splenomegaly = T-cell hyperplasia = Periarterial lymphatic sheath PALS
3. High WBC - Atypical lymphocytes in the blood

Question 5

IM screening test ?

Answer 5

The monospot test

Question 6

Monospot test procedure ?

Answer 6

1. Detects IgM AB that reacts with horse/sheep red blood cells
2. Turns positive within 1 week after infection
   3.A negative monospot test suggests- CMV cause in IM
   4.Definitve diagnosis = Serologic test = EBV viral capsid antigen

Question 7

A negative monospot test suggests ?

Answer 7

CMV cause in IM

Question 8

Serological definitve diagnosis ?

Answer 8

EBV viral capsid antigen

Question 9

Complications of Infectious mononucleosis ?

Answer 9

1. Splenic rupture
2. Rash if exposed to Ampicillin
3. Dormancy of virus in B cells leads to increase risk for B cell lymphoma + HIV

Question 10

Splenic rupture in IM Tx ?

Answer 10

Avoid contact sports for one month