Leukopenia

Question 1

Leukopenia WBC Count ?

Answer 1

< 5K / micro litre

Pathoms-53

Question 2

Decreased number of circulating neutrophils are called ?

Answer 2

Neutropenia

Question 3

Neutropenia causes ?

Answer 3

1. Drug toxicity -Chemotherapy with alkalying agents
2. Severe infection - Gram (-) Sepsis

Question 4

Neutropenia Tx ?

Answer 4

GM-CSF / G-CSF

Question 5

Decreased number of circulating lymphocytes ?

Answer 5

Lymphopenia

Question 6

Lymphopenia causes ?

Answer 6

1. Immunodeficiency -DiGeorge syndrome + HIV
2. High cortisol-Cushing syndrome = Induce apoptosis of lymphocytes
3. Autoimmune destruction - SLE
4. Whole body radiation

Question 7

Highly sensitive to radiation >?

Answer 7

Lymphocytes

Question 8

Hematopoiesis from which cell ?

Answer 8

Hematopoietic CD 34+ stem cells

Question 9

Hematopoietic CD34+ STEM cell types ?

Answer 9

1. Myeloid stem cell
2. Lymphoid stem cell

Question 10

Lymphoid stem cells derivatives ?

Answer 10

1. B-Lymphocyte = Naive B cells = Plasma cells
2. T-Lymphocyte = Naive T cells = CD 4+ /CD 8+ Cells

Question 11

Myeloid stem cell derivatives ?

Answer 11

1. Erythroblast = RBC
2. Myeloblast = PHILS = Neutro-Eosino-Baso
3. Monoblast = Monocytes
4. Megakaryoblast = Megakaryocytes