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USMLE-Pathology-(Pathoma+ FA+UWorld) > Vasculitis > Flashcards

Vasculitis Flashcards

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USMLE® Step 1 flashcards
1
Q

Arterial wall layer ?

P-65

A
  1. Intima = Endothelial
  2. Media = Smooth muscle
  3. Adventitia = Connective tissue
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2
Q

Inflammation of the blood vessel wall ?

Pathoma-65

A

Vasculitis

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3
Q

Small vessel vasculitis branches ?

P-65

A
  1. Arterioles
  2. Capillaries
  3. Venules
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3
Q

Medium vessel vasculitis branches ?

P-65

A

Muscular arteries & that supply organs

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4
Q

Large vessel vasculitis branches ?

P-65

A

Aorta & its major branches

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5
Q

Clinical features of Vasculitis ??

P-65

A
  1. Fever
  2. Fatigue
  3. Weight loss
  4. Malaise
  5. Organ ischemia - thrombosis of the inflammed vessels
  6. Healing - Fibrosis

P-65

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6
Q

Large vessels vasculitis example ?

2 example

P-65

A
  1. Temporal/Giant cell A - Carotid A
  2. Takayasu A - Aortic arch at branch
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6
Q

Tx of large vessels vasculitis ?

P-65

A

Corticosteroids

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7
Q

Granulomatous vasculitis that involves branches of the carotid artey ?

p

A

Temporal / Giant cell arteries vasculitis

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7
Q

Age of occurance of large vessels vasculitis ?

p-65

A
  1. Temporal / Giant A = >50yr
  2. Takayasu A = <50yr
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8
Q

ESR level in large vessels vasculitis ?

A

Elevated

P=-65

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9
Q

Clinical features of temporal / giant artery vasculitis ?

A
  1. Headache - Temporal Artery
  2. Visual disturbance - OPthalmic A
  3. Jaw claudication
  4. Flu like symptoms
  5. Muscle & joint pain - Polymyalgia rheumatica
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10
Q

Biopsy result of temporal / giant A vasculuitis ?

P-65

A

-inflammed vessel wall
-with giant cells and intimal fibrosis

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11
Q

Pulse less disease ??

p-65

A

Takayasu arteries

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11
Q

Lesions are segmented - thats why biopsy need —-???

P-65

A

A long segment of vessels ,
(-) biopsy doesnot exclude disease

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12
Q

Medium vessels vasculitis examples??

P-65

A
  1. Polyarthritis nodosa
  2. Kawasaki disease
  3. Buerger disease
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13
Q

Polyarteritis nodosa meaning >??

P-65

A

Necrotizing vasculitis involving multiple organs , lungs are spoared

14
Q

Classical presenattion of polyarteritis’ nodosa ??

P-65

A
  1. HTN - Renal A
  2. Ab pain - Mesenteric A
  3. Skin lesion
  4. Neurologic disturbance
15
Q

Assocition of PN ?

A

HBsAg

16
Q

Early lesion features of PN >

P-66

A

Transmural inflammation with fibrinoid necrosis

16
Q

Tx of PN ?

P-66

A
  1. Corticosteroids
  2. Cyclophosphamide
17
Q

Healing process of PN ??

P-66

A

Fibrosis

17
Q

Tx of Kawasaki disease ??

P-66

A

Aspirine

{{{most exceptional case }}}

18
Q

Imaging show of PN ?

A

String of pearls appearance

P-66

19
Q

Coronary artery involvement in kawasaki disease ??

p-66

A
  1. MI + Thrombosis
  2. Aneurysm + Rupture
19
Q

Clinical presentation of buerger disease ??

p-66

A
  1. Ulceration
  2. Gangrene
  3. Autoamputation of finger and toes
  4. Raynaud phenomenon
20
Q

Raynaud phenomenon involvement in which vasculitis ??

Pathoma-66

A

Buerger disease

20
Q

Classical presentation of kawasaki diusease ??

A
  1. Fever
  2. Conjunctivitis
  3. Erythematous rash of plam & sole
  4. Enlarged cervical lymph node
    1. age <4yr old asian children
21
Q

Heavy smoking association in which vasculitis ??

P-66

A

Buerger disease

22
Q

Tx of buerger disease >??

P-66

A

Cessation of smoking

23
Q

Tx of wegener granulomatosis ??

P-66

A
  1. Cyclophosphamide
  2. Steroids
23
Q

Small vessel vasculitis examples ??

P-66

A
  1. Wegener granulomatosis
  2. Microscopic polyangitis
  3. Churg strauss syndrome
  4. Henoch schonlein purpura
24
Q

Necrotizing granulomatous vasculitis including which site cause - Wegener Granulomatosis ??

P-66

A
  1. Nasophaynx
  2. Lung
  3. Kidneys
25
Q

Which serum marker in wegener granulomatosis ??

P-66

A

c-ANCA

26
Q

p-ANCA serum level in which disease ??

P-66

A
  1. Microscopic polyangitis
  2. Churg strauss syndrome
27
Q

Classical presenattion of wegener granulomatosis ??

A
  1. Sinusitis
  2. Nasopharangeal ulceration
  3. Hemoptysis
  4. Bilateral nodular lung infiltrates
  5. Hematuria
  6. Rapidly Progressive Glomerulonephritis
28
Q

Features of churg strauss syndrome ?

A
  1. Asthma
  2. Peripheral eosinophilia

P-66

29
Q

Vasculitis + IgA immune complex deposition = ??

P-67

A

Henoch schonlein purpura

29
Q

Wegenar granulomatosis vs Microcopic polyangitis ??

A

WG – Nasopharyngeal + granuloma present ‘
MP == Absent

30
Q

Henoch schonlein purpura Tx ?

A

Steroids

31
Q

Henoch schonlein purpura clinical feature ???

A
  1. Palpable purpura on legs & buttoks
  2. GI pain
  3. Bleeding
  4. Hematuria
  5. IgA nephropathy
  6. URT infection

P-67

USMLE-Pathology-(Pathoma+ FA+UWorld) (75 decks)

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