Langerhans Cell Histocytosis

Question 1

Langerhans cell ?

Answer 1

Dendritic cells in skins

64

Question 2

LC derived from ?

Answer 2

Bone marrow monocytes

Question 3

LCH ?

Answer 3

Neoplastic proliferation of langerhans cells

Question 4

Birbeck-Tennis racket granules in HISTO slide

Answer 4

LCH

Question 5

Immunohistochemistry of LCH ?

Answer 5

1. CD1a+
2. S-100+

Question 6

Benign proliferation of LC ?

Answer 6

Eosinophilic granuloma

Question 6

Malignant proliferation of LC ?

Answer 6

Letterer siwe disease

Question 7

LSD presentation ?

Answer 7

1. skin rash
2. cystic skeletal defects in infant

multiple organ + Fatal

Question 8

EG presentation ?

Answer 8

1. Skin not involed
2. Pathologic fracture in adolescent

Question 9

EG-Biopsy >?

Answer 9

1. LC
2. Inflammatory cells
3. Numerous neutrophils

Question 10

Malignant proliferation of LC ?

Answer 10

Hand schuller christian D

1.Scalp rash
2.lytic skull defects
3.Diabetes insipidus
4.Exopthalmus in a child