Acute Myeloid Leukemia

Question 1

Myeloblasts + cytoplasmic staining for what ?

Answer 1

Myeloperoxidase
MPO

Pathoma-56

Question 2

Acute myeloid leukemia ?

Answer 2

Neoplastic proliferations of immature myeloid cells >20%

Question 3

t (15-17) translocation in Acute promyelocytic leukemia ?

Answer 3

Chromosme-17 Retinoic acid receptor translocate to chromosome-15

RAR disruption block -maturation and promyelocyte blast accumulate

Question 3

Myeloperoxidase characteristics in Acute myeloid leukemia ?

Answer 3

Crystal aggregate
AUER rods

Question 3

AML common age ?

Answer 3

Older patient-50-60 year

Question 4

Acute promyeloblastic leukemia cause ?

Answer 4

1. t ( 15-17)

Question 4

Subclasses of acute myeloid leukemia ?

Answer 4

1. Acute promyelocytic leukemia
2. Acute monocytic leukemia
   3.Acute megakaryoblastic leukemia

Question 5

Abnormal promyelocyte increas risk of which disease ?

Answer 5

DIC

Question 6

Tx of APL in AML ?

Answer 6

All trans retinoic acid - ATRA
vitamin-A derivatives

ATRA binds with the receptor= Blast mature

Question 7

Acute monocytic leukemia ?

Answer 7

Proliferation of monoblasts

Question 8

AMonocyticL IN AML ?

Answer 8

1. Lack of MPO
2. Inflitrate Gum - Figure -56

Question 9

Acute Megakaryoblastic leukemia ?

Answer 9

1. Lack MPO
2. Down syndrome
3. Before age 5

Question 10

AML arise from which ?

Answer 10

1. Preexisting dysplasia
2. Myelodysplastic syndrome
3. Chemotherapy or Radiation

Question 11

Myelodysplastic syndrome features ?

Answer 11

1. Hypercellular bone marrow
2. Inc blasts
3. Cytopenia
4. Abnormal amturation of cells

Most patient dir from infection / Bleeding

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