Arteriosclerosis

Question 1

Arteriosclerosis meaning ??

P-68

Answer 1

Hard arteries = Thickening of the blood vessel wall

Question 2

Arteriosclerosis types ??

P-687

Answer 2

1. Atherosclerosis
2. Arteriolosclerosis
3. Monckeberg medial calcific sclerosis

P-68

Question 2

Atherosclerosis in which layer ??

Answer 2

Intimal plaque - obstruct blood flow

P-68

Question 3

Parts of atherosclerosis??

Answer 3

1. Necrotic lipid core = Cholesterol
2. Fibromuscluar cap

P-68

Question 4

Which calcification in atherosclerosis??

Answer 4

Dystrophic

P

Question 5

Involves artery of atherosclerosis >?

Answer 5

ACPI
A=Abdominal aorta
C=Coronary artery
P=Popliteal artery
I = Internal carotid a

po

Question 6

Modifiable risk factors of atherosclerosis??

Answer 6

1. HTN
2. Hypercholesterolemia
3. LDL inc
4. HDL dec
5. Smoking
6. Diabetes

P-68

Question 7

Non-modifiable risk factors of atherossclerosis ??

P-68

Answer 7

1. Age
2. Gender
3. Genetics
4. Fmaily history is highly predictive risk factors
5. Male + Post menopausal female

Question 8

Pathogenesis of atherosclerosis??

A BIG SHIT ????

Answer 8

-Damage of endothelium
-Leak of lipid to the intima
-Lipid gets oxidized
-Taken up by macrophage (scavenger receptor )
-Foam cells formation
-Inflammation and healing
-Deposition of ECM
-Proliferation of smooth muscle = Fibromuscular cap

Question 9

Fibromuscular cap formation ??

P-68

Answer 9

Smooth muscle + ECM

P-69

Question 9

Morphology of atherosclerosis??

Answer 9

=Fatty streaks
=Flat yellow lesion of the intima
=Lipid laden macrophage

P-69

Question 10

Progression of atherosclerosis?

Answer 10

Atherosclerosis plaque

P-69

Question 11

Stenosis of medium sized arteries impaired blood flow and ischemia —leads to -

3 artery atherosclerosis = 3 pathogenesis

Answer 11

1. Coronary artery = Angina
2. Popliteal a= Peripheral vascular disease
3. Mesenteric a =Ischemic Bowel d

P-69

Question 12

Narrowing of small arterioles is called ??

Answer 12

Arteriolosclerosis

Question 12

Plaque rupture complication in atherosclerosis??

Answer 12

1. Coronary artery = MI
2. Middle cerebral a = stroke

P-69

Question 13

Weaking of the vessel wall + Atherosclerosis = ??

Answer 13

Abdominal aorta = Aneurysm

P-69

Question 13

Plaque rupture + Embolization = ??

Answer 13

Atherosclerotic emboli
= cholesterol crystals

Question 14

Arteriolosclerosis type ??

Answer 14

1. Hyaline
2. Hyperplastic

P-69

Question 15

Protein leaking in the vessel wall ??

Answer 15

Hyaline type

Question 16

Result of hyaline arteriolosclerosis ??

Answer 16

1. Glomerular scarring
2. Arteriolonephrosclerosis
3. Chronic renal failure

P-69

Question 16

Hyaline type protein leak are seen in histo >????

Answer 16

Pink hyaline on microscopy

P-69

Question 17

HYperplastic type def ??

Answer 17

Thickening of the vessel wall by hyperplasia of smooth muscle

Question 17

Onion like appearnace ??

Answer 17

Hyperplastic arteriolosclerosis

p-69

Question 18

Which necrosis in hyperplastic type >??

Answer 18

Fibrinoid Necrosis

P-69

Question 19

Flea bitten appearance where ??

Answer 19

1. Pinpoint hemorrhage
2. Acute renal failure
3. Reduced blood caliber with end organ ischemia

P-69

Question 20

Calcification of the media of muscular arteries ??

no clinical shit ??

Answer 20

Monckeberg medial calcific sclerosis

P-69