Arteriosclerosis Flashcards
Arteriosclerosis meaning ??
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Hard arteries = Thickening of the blood vessel wall
Arteriosclerosis types ??
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- Atherosclerosis
- Arteriolosclerosis
- Monckeberg medial calcific sclerosis
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Atherosclerosis in which layer ??
Intimal plaque - obstruct blood flow
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Parts of atherosclerosis??
- Necrotic lipid core = Cholesterol
- Fibromuscluar cap
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Which calcification in atherosclerosis??
Dystrophic
P
Involves artery of atherosclerosis >?
ACPI
A=Abdominal aorta
C=Coronary artery
P=Popliteal artery
I = Internal carotid a
po
Modifiable risk factors of atherosclerosis??
- HTN
- Hypercholesterolemia
- LDL inc
- HDL dec
- Smoking
- Diabetes
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Non-modifiable risk factors of atherossclerosis ??
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- Age
- Gender
- Genetics
- Fmaily history is highly predictive risk factors
- Male + Post menopausal female
Pathogenesis of atherosclerosis??
A BIG SHIT ????
-Damage of endothelium
-Leak of lipid to the intima
-Lipid gets oxidized
-Taken up by macrophage (scavenger receptor )
-Foam cells formation
-Inflammation and healing
-Deposition of ECM
-Proliferation of smooth muscle = Fibromuscular cap
Fibromuscular cap formation ??
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Smooth muscle + ECM
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Morphology of atherosclerosis??
=Fatty streaks
=Flat yellow lesion of the intima
=Lipid laden macrophage
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Progression of atherosclerosis?
Atherosclerosis plaque
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Stenosis of medium sized arteries impaired blood flow and ischemia —leads to -
3 artery atherosclerosis = 3 pathogenesis
- Coronary artery = Angina
- Popliteal a= Peripheral vascular disease
- Mesenteric a =Ischemic Bowel d
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Narrowing of small arterioles is called ??
Arteriolosclerosis
Plaque rupture complication in atherosclerosis??
- Coronary artery = MI
- Middle cerebral a = stroke
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Weaking of the vessel wall + Atherosclerosis = ??
Abdominal aorta = Aneurysm
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Plaque rupture + Embolization = ??
Atherosclerotic emboli
= cholesterol crystals
Arteriolosclerosis type ??
- Hyaline
- Hyperplastic
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Protein leaking in the vessel wall ??
Hyaline type
Result of hyaline arteriolosclerosis ??
- Glomerular scarring
- Arteriolonephrosclerosis
- Chronic renal failure
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Hyaline type protein leak are seen in histo >????
Pink hyaline on microscopy
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HYperplastic type def ??
Thickening of the vessel wall by hyperplasia of smooth muscle
Onion like appearnace ??
Hyperplastic arteriolosclerosis
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Which necrosis in hyperplastic type >??
Fibrinoid Necrosis
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Flea bitten appearance where ??
- Pinpoint hemorrhage
- Acute renal failure
- Reduced blood caliber with end organ ischemia
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Calcification of the media of muscular arteries ??
no clinical shit ??
Monckeberg medial calcific sclerosis
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