Hyperthyroidism-Graves Disease

Question 1

Hyperthyroidism associated Antigen ??

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Answer 1

HLA-DR3
HLA-B8

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Question 2

Which hypersensitivity inn graves disease ?/

Answer 2

Type-2 Hypersensitivity

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Question 3

M/A of graves disease ??

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Answer 3

Thyroid stimulating Ig – Binds TSH R – INC T3 T4

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Question 4

Exopthalmos M/A ??

Answer 4

T cell activation – Lymphocyte infiltration retro orbital space – inc TNF-A IFN-Gama – Inc fibroblast secretion – Inc muscle inflmma – Osmotic muscle sweeling

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Question 5

Histology of graves disease ??

Answer 5

1. Tall
2. Crowded Collumnar follicular epithelial cells
3. Salloped colloid

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Question 6

Dx of graves disease ??

Answer 6

1. inc T3 T4
2. dec TSH
3. inc Anti TSH R
4. Diffuse uptake on thyroid scintigraphy

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Question 6

Lipid profile in graves diseaae ??

Answer 6

1. dec Cholesterol
2. dec TAG
3. CBC monocytic anemia

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Question 7

Presentation of graves disease ??

Answer 7

1. Exopthalmos
2. Pretibial myxedema
3. Goiter
4. Graves opthalmopathy
5. Lid retraction

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Question 7

Thyroid storm ??

Answer 7

Life threatening complication of graves disease if it remains untreated

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Question 8

Thyroid storm caused by —

Answer 8

1. Acute stress
2. Trauma
3. Infection

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Question 8

Tx of Graves orbitopathy ??

FA-346

Answer 8

Glucocorticoids

FA 346

Question 9

Associated complications of thyroid storm ?/

Answer 9

1. Fever
2. Coma
3. Delirium
4. Diarrhea
5. Agitation
6. Tachyarrhythmia

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Question 9

Tx of thyroid storm ?/

Answer 9

1. Propanolol
2. Propylthiouracil
3. Prednisolone
4. Potassium iodide

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Question 9

Wolff chaikoff effect ??

Answer 9

Iodide load – dec T4 synthesis - WC E

FA-346

Question 10

Fetal hyperthyroidism??

Answer 10

TSI Ig crosses placenta – Hyperthyroidism in utero

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Question 11

Tx of hyperthyroidism in mother ??

Answer 11

Methimazole

Question 12

Which nodules are not malignant ??

Answer 12

Hot nodules

FA 346

Question 13

Hot nodules in toxic multinodular goiter ??

Answer 13

Hyperfunctioning nodules visualized on radioactive iodine scan

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Question 14

Autonomous thyroid hormone synthesis – G D – Toxic multinodular goiter ???

Answer 14

Jod basedow phenomenon

Question 15

Smooth / Diffuse goiter ??

Answer 15

1. G D
2. Hashimoto thyroiditis
3. Iodine insufficiency
4. TSH secreting pituitary adenoma

FA 346

Question 16

Nodular goiter ??

Answer 16

1. Toxic multinodula goiter
2. T adenoma
3. T cancer
4. t cyst

FA 346

Question 17

Presentation: Often patients seeking rapid weight loss with access to exogenous thyroid hormones, symptoms of hyperthyroidism Dx ??

Answer 17

INC T3 T4
dec TSH
dec Thyroglobulin level
low/undetectable 24 hr radioiodine uptake

Question 18

Muskuloskeletal in hyperthyroidism??

Answer 18

1. Thyrotoxic myopathy
2. Osteoporosis
3. Inc fracture rate

FA 344

Question 18

Hyperthyroidism in GIT ??

Answer 18

1. GI motility inc
2. Diarrhea
3. Inc appetite
4. Hyperdefecation

FA-344

Question 19

Reproductive Hyperthyroidism??

Answer 19

1. Abnormal uterine bleeding
2. Gynecomastia
3. dec Libido
4. Infertility

FA 344

Question 20

Skin /hair in hyperthyroidism??

Answer 20

1. Warm
2. Moist skin - vasodilation
3. Fine hair
4. Onycholysis
5. Pretibial myxedema GD

FA 344