Hyperthyroidism-Graves Disease Flashcards
Hyperthyroidism associated Antigen ??
HLA-DR3
HLA-B8
PDF BC
Which hypersensitivity inn graves disease ?/
Type-2 Hypersensitivity
PDF BC
M/A of graves disease ??
BC PDF
Thyroid stimulating Ig – Binds TSH R – INC T3 T4
PDF BC
Exopthalmos M/A ??
T cell activation – Lymphocyte infiltration retro orbital space – inc TNF-A IFN-Gama – Inc fibroblast secretion – Inc muscle inflmma – Osmotic muscle sweeling
PDF BC
Histology of graves disease ??
- Tall
- Crowded Collumnar follicular epithelial cells
- Salloped colloid
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Dx of graves disease ??
- inc T3 T4
- dec TSH
- inc Anti TSH R
- Diffuse uptake on thyroid scintigraphy
PDF BC
Lipid profile in graves diseaae ??
- dec Cholesterol
- dec TAG
- CBC monocytic anemia
PDF BC
Presentation of graves disease ??
- Exopthalmos
- Pretibial myxedema
- Goiter
- Graves opthalmopathy
- Lid retraction
PDF BC
Thyroid storm ??
Life threatening complication of graves disease if it remains untreated
PDF BC
Thyroid storm caused by —
- Acute stress
- Trauma
- Infection
PDF BC
Tx of Graves orbitopathy ??
FA-346
Glucocorticoids
FA 346
Associated complications of thyroid storm ?/
- Fever
- Coma
- Delirium
- Diarrhea
- Agitation
- Tachyarrhythmia
PDF BC
Tx of thyroid storm ?/
- Propanolol
- Propylthiouracil
- Prednisolone
- Potassium iodide
4 P
Wolff chaikoff effect ??
Iodide load – dec T4 synthesis - WC E
FA-346
Fetal hyperthyroidism??
TSI Ig crosses placenta – Hyperthyroidism in utero
PDF BC
Tx of hyperthyroidism in mother ??
Methimazole
Which nodules are not malignant ??
Hot nodules
FA 346
Hot nodules in toxic multinodular goiter ??
Hyperfunctioning nodules visualized on radioactive iodine scan
PDF BC
Autonomous thyroid hormone synthesis – G D – Toxic multinodular goiter ???
Jod basedow phenomenon
Smooth / Diffuse goiter ??
- G D
- Hashimoto thyroiditis
- Iodine insufficiency
- TSH secreting pituitary adenoma
FA 346
Nodular goiter ??
- Toxic multinodula goiter
- T adenoma
- T cancer
- t cyst
FA 346
Presentation: Often patients seeking rapid weight loss with access to exogenous thyroid hormones, symptoms of hyperthyroidism Dx ??
INC T3 T4
dec TSH
dec Thyroglobulin level
low/undetectable 24 hr radioiodine uptake
Muskuloskeletal in hyperthyroidism??
- Thyrotoxic myopathy
- Osteoporosis
- Inc fracture rate
FA 344
Hyperthyroidism in GIT ??
- GI motility inc
- Diarrhea
- Inc appetite
- Hyperdefecation
FA-344
Reproductive Hyperthyroidism??
- Abnormal uterine bleeding
- Gynecomastia
- dec Libido
- Infertility
FA 344
Skin /hair in hyperthyroidism??
- Warm
- Moist skin - vasodilation
- Fine hair
- Onycholysis
- Pretibial myxedema GD
FA 344
