Vulva Pathology Female Reproductive Flashcards
Vulva lining epithelium ?
Squamous epithelium
Vulva contain skin and mucous of which anatomical external orhans of female ?
- Labia majora
- Labia minora
- Mons pubis
- Vestibule
Cystic dilation of the bartholin gland ?
Bartholin cyst
Cause of bartholin cyst ?
- Inflammatioon
- Obstruction of gland
Hallmark of HPV infected cells in condyloma ?
koilocytes
koilocytic changes
Location of bartholin gland ?
Each side of vaginal canal
= produce mucous like fluid
=drains via ducts into the lower vestibule
Presentation of bartholin cyst ?
- Unilateral
- Painful
- Cystic lesion at the lower vestibule
Progression of condyloma ?
Carcinoma
less risk - type 6/11 HPV
Warty neoplasm of vulvular skin often large ?
Condyloma
Causes of condyloma ?
- HPV 6/11 -condyloma acuminatum
- Secondary syphilis - C latum
Pathoma-137
Presentation of lichen sclerosis ?
- Leukoplakia = White patch
- Parchment like vulvar skin
Lichen sclerosis characterized by —
- Epidermis = Thinining
- Dermis = Fibrosis / sclerosis
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Common whom ?
Lichen sclerosis
Postmenopausal women
Ca association of lichen sclerosis ?
Benign
Squamous Cell Ca
Lichen simplex chronicus cause ?
Squamous epithelium of vulva= Hyperplasia
Presentation of lichen simplex chronicus ?
- Leukoplakia=White patch
- Leathery vulvar skin
Association of lichen simplex chronicus ?
- Scratching
- Chronic irritation
Ca association of LSC ?
Benign
no chance of Squmous cell Ca
Lichen sclerosis VS
Lichen Simplex Chronicus ?
- LS=Parchment like vulvar skin
- LSC=Lethery vulvar skin
Carcinoma of vulva ?
Squamous cell of vulva
Causes of vulvar carcinoma ?
- HPV cause - HPV-16/18
- Non-HPV - Long standing lichen sclerosis
VIN characteristics?
- Dysplastic lesion
- Koliocytic change
- Disordered cellular maturation
- Nuclear atypia
- inc mitotic activity
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Vulvar carcinoma arise from which neoplasia ?
Vulvar intraepithelial neoplasia
VIN
Presentation of extramammary paget disease ?
- Erythematous
- Pruritic
- Ulceeated vulvar skin
Presenation of paget d in skinn?
Carcinoma in situ
No underlying carcinoma
Non-HPV vulvar Ca seen in —
Elderly women - >70yr
Malignant epithelial cells in the epidermis of the vulva ?
Extramammary paget disease
Paget disease in nipple vs Vulva ?
- PD in vulva = No underlying carcinoma
- PD in nipple = Underlying carcinoma
PD in vulva should be distinguish from ?
Melanoma
Melanoma vs PD vulva
- PD in vulva - PAS+ Keratin+ S-100-
- Melanoma- PAS- Keartin- S-100+
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