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Physiology > WBCs, Immunity and Infection > Flashcards

WBCs, Immunity and Infection Flashcards

1
Q

INNATE IMMUNITY

1st line
non specific
does NOT require prior exposure
less powerful

COMPLEMENT

A 
phagocytes
monocytes
macrophages
neutrophils
NK cells
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2
Q

ADAPTIVE IMMUNITY

2nd line
specific
requires prior exposure
more powerful

ANTIBODIES

A

lymphocytes (T, B and plasma cells)

antigen presenting cells (macrophages, B and dendritic cells)

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3
Q

Links innate to adaptive immunity

A

Dendritic cells

“sentinels” that capture process and present antigens to lymphoid tissues to select rare, antigen-reactive T cell clones

also acts as sensors responding to spectrum of environment cues by extensive differentiation or maturation

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4
Q

Types of Adaptive Immunity

A

Humoral Immunity

Cell Mediated Immunity

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5
Q

Main Cells of Humoral Immunity

A

B lymphocytes

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6
Q

Main Cells of Cell Mediated Immunity

A

T lymphocytes

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7
Q

HUMORAL IMMUNITY

A

originated and matured in the BONE MARROW

protect against EXTRACELLULAR microbes and their toxins
toxin induced diseases
infections

SUPERFICIAL cortex

WHITE PULP

differentiation of B cells into antibody secreting cells called PLASMA CELLS

antibodies are formed

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8
Q

CELL MEDIATED IMMUNITY

A

originated in the bone marrow and matured in the THYMUS

protect against INTRACELLULAR microbes and their toxins

  • viruses
  • parasites
  • bacteria

kills tumor cells

PARACORTICAL areas

PERIARTERIOLAR LYMPHOID SHEATHS (PALS)

secrete CYTOKINES

antibodies not formed

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9
Q

Antibody mediated hypersensitivity reactions

A

I, II, III

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10
Q

Cell mediated hypersensitivity reactions

A

IV

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11
Q

Cells involved in Humoral Immunity

A

Antibody synthesis requires 3 cells:

T lymphocytes
B lymphocytes
Macrophage

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12
Q

Cells involved in Cell Mediated

A

Macrophage
Helper T cells
Natural killer T cells
Cytotoxic T cells

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13
Q

MC type of WBCs

bacterial infection and ACUTE inflammation

A

NEUTROPHILS

multilobed nucleus

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14
Q

Parasitic infections and allergies

Highly phagocytic for antigen-antibody (immune) complexes

A

EOSINOPHILS

bilobed nucleus

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15
Q

LEAST COMMON type

produce histamine, heparin, bradykinin, serotonin

A

BASOPHILS

bilobed/trilobed nucleus

mast cells: degranulation –> allergy to anaphylaxis

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16
Q

Phagocytes
LARGEST of WBC
mature into MACROPHAGE (tissues)
activated by INTERFERON GAMMA

A

MONOCYTES

large kidney shaped nucleus
frosted glass or ground glass cytoplasm

17
Q

Small, biconvex, non nucleated cells from megakaryocytes

NOT a WBC

A

PLATELETS

7-10 days

Physiology (98 decks)

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