Synthesis of Adrenocortical Hormones Flashcards
Aldosterone synthase, an enzyme used in aldosterone synthesis, is activated by
Angiotensin II
hormone secreted by the hypothalamus acts on the anterior pituitary to secrete adrenocorticotropic hormone, which acts on the adrenal cortex to secrete adrenocortical hormones
Coritcotropin Releasing Hormones
The secretion of corticotropin-releasing hormone from the hypothalamus is (stimulated/inhibited) by cortisol.
Inhibited
The middle layer of the adrenal cortex is called and it secretes glucocorticoids.
Zona Fasciculata
The zona glomerulosa layer of the adrenal cortex secretes .
Mieralocorticoids
In glucocorticoid synthesis, 17-hydroxyprogesterone is converted to 11-deoxycortisol by .
21 hydroxylase
The first step in the biosynthesis of adrenocortical hormones is converting cholesterol to pregnenolone by .
Cholesterol desmolase
Aldosterone secretion is regulated primarily through extracellular fluid volume changes by the system.
RAAS
A low dose of in a healthy person inhibits adrenocorticotropic hormone secretion.
Dexamethasone
Increased serum K+ concentration depolarizes adrenal cells and opens channels, which stimulates the adrenal cortex to secrete aldosterone.
voltage sensitive calcium channels
Corticotropin-releasing hormone secreted by the acts on the anterior pituitary to secrete adrenocorticotropic hormone, which acts on the adrenal cortex to secrete adrenocortical hormones.
Hypothalamus
Progesterone is converted to 17-hydroxyprogesterone in the synthesis of glucocorticoids or androgens by .
17 alpha hydroxylase
Cholesterol desmolase, the first and rate-limiting enzyme used in the biosynthesis of adrenocortical hormones, is activated by .
ACTH
The conversion of angiotensinogen to angiotensin I is catalyzed by .
Renin
The conversion of angiotensin I to angiotensin II is catalyzed by .
ACE
In glucocorticoid synthesis, 11-deoxycortisol is converted to cortisol by .
11 beta-hydroxylase
Aldosterone secretion is stimulated by a(n) (increase/decrease) in extracellular fluid volume.
DECREASE
The outermost layer of the adrenal cortex is called and it secretes mineralocorticoids.
Zona Glomerulosa
Aldosterone secretion increases with (increased/decreased) serum K+ concentration.
Increased
The zona fasciculata layer of the adrenal cortex secretes .
Glucocorticoids
Na+ reabsorption in the kidney is stimulated by (hormone) to help restore extracellular fluid volume.
Aldosterone
the main glucocorticoid produced by the adrenal cortex.
Cortisol
The zona reticularis layer of the adrenal cortex secretes
Androgens
In mineralocorticoid synthesis, corticosterone is converted to aldosterone by .
Aldosterone synthase
Corticotropin-releasing hormone secreted by the hypothalamus acts on the anterior pituitary to secrete adrenocorticotropic hormone, which acts on the adrenal cortex to secrete hormones.
Adrenocortical
The rate limiting enzyme in the biosynthesis of adrenocortical hormones is .
CHOLESTEROL DESMOLASE
The innermost layer of the adrenal cortex is called and it secretes androgens.
Zona reticularis
Corticotropin-releasing hormone secreted by the hypothalamus acts on the anterior pituitary to secrete hormone, which acts on the adrenal cortex to secrete adrenocortical hormones.
ACTH
