Microcirculation and Lymph

Question 1

Starling Forces

Capillary Hydrostatic Pressure - FILTRATION (positive)
Capillary Oncotic Pressure - ABSORPTION (negative)
Interstitial Hydrostatic Pressure - ABSORPTION (negative)
Interstitial Oncotic Pressure - FILTRATION (positive)

Answer 1

Jv = Kf (Pc-Pi) - (^c - ^i)

Jv = fluid movement
Kf = hydraulic conductance
Pc = capillary hydrostatic pressure
Pi = interstitial hydrostatic pressure
pi c = capillary oncotic pressure
pi i = interstitial oncotic pressure

Question 2

Occurs when INTERSTITIAL FLUID EXCEEDS the capacity of the lymphatics to return it to the circulation

D.t. EXCESS FILTRATION or BLOCKED LYMPHATICS

Answer 2

EDEMA

Histamine — arteriolar dilation and venous constritiction —> LARGE INC in Pc and local edema

Question 3

INCREASE CAPILLLARY HYDROSTATIC PRESSURE

Answer 3

arteriolar ilation
venous constriction
increased venous pressure
HF
extracellular volume expansion
standing (edema in dependent limbs)

Question 4

DECREASE CAPILLARY ONCOTIC PRESSURE

Answer 4

decreased plasma concentration
severe liver disease (failure to synthesize proteins)
protein malnutrition
nephrotic yndrome (loss of protein in the urine)

Question 5

INCREASE HYDRAULIC CONDUCTANCE

Answer 5

burn

inflammation (release of histamine;cytoine)