Hemostasis

Question 1

Steps of Hemostasis

Answer 1

1. Vascular Constriction
2. Primary Hemostasis (Formation of Loose Platelet Plug)
3. Secondary Hemostasis (Blood Coagulation)
4. Resolution

Question 2

Due to LOCAL MYOGENIC SPASM, ET-1

Answer 2

Vascular Constriction

Question 3

Platelet adhesion

Answer 3

Mediated by vWF of ruptured blood vessels walls and Gp1b of platelets

Question 4

Platelets change shape

Answer 4

Platelet activation

Question 5

Extrinsic and Intrinsic pathway leads to formation of THROMBIN – fibrinogen –> fibrin (meshwork that strengthens the loose platelet plug)

Answer 5

Secondary Hemostasis (Blood Coagulation)

Question 6

D.t FIBRINOLYSIN or PLASMIN

Answer 6

Resolution

Question 7

Binds to serine proteases in the coagulation system

(-) active forms of factors IX, X, XI and XII

Answer 7

Antithrombin III

Question 8

Expressed in all endothelial cells except in cerebral microcirculation

Binds to thrombin and turns it into an anticoagulant

Answer 8

Thrombomodulin

Question 9

Lyse fibrin and fibrinogen

Answer 9

Plasmin

Question 10

Binds to antithrombin III –> inactivates thrombin and factor Xa

Answer 10

Heparin