Renal Tubular Systen

Question 1

Movement from Glomerular Capillaries to Bowman’s Space

Answer 1

FILTRATION (Glomerular)

Question 2

Movement from Tubules to Interstitium to Peritubular Capillaries

Answer 2

REABSORPTION (Tubular)

Question 3

Movement from Peritubular Capillaries to Interstitium to Tubules

Answer 3

SECRETION (Tubules)

Question 4

Excretion

Answer 4

Amount Filtered - Amount Reabsorbed + Amount Secreted

Question 5

“Workhorse” of the nephron

MOST SUSCEPTIBLE TO HYPOXIA AND TOXINS

Answer 5

PCT

(+) microvilli, convolutions

Question 6

Occurs in PCT from lumen to the PCT cell to peritubular capillaries

Answer 6

Isosmotic Fluid Reabsorption

Question 7

Site of Reabsorption of Na, H20, HCO3 and glucose

Answer 7

EARLY PCT

Question 8

Loop of Henle

Answer 8

Descending Limb
Thin Ascending Limb
Thick Ascending Limb

Question 9

Permeable to water

Impermeable to solutes

Answer 9

DESCENDING LIMP of LOH

Question 10

Permeable to solutes
Impermeable to solutes
Diluting segment

Answer 10

Ascending limb
THICK Ascending Limb of LH (TAL of LH)
*Na K 2 Cl symport seen here

Question 11

Cortical diluting segment

site of MACULA DENSA

Answer 11

Early Distal Tubule

Question 12

Site of action of ALDOSTERONE

Answer 12

LATE DISTAL TUBULE

Principal cells - reabsorb Na (and water)
*secrete K

Intercalated cells - reabsorb K
*secrete H+

Question 13

Site of ADH

Answer 13

Collecting Duct

increase ADH – increase aquaporin 2 channels – increase water reabsorption

Question 14

Countercurrent MULTIPLIER

CREATES GRADED OSMOLARITY in renal media

Answer 14

Loop of Henle

Question 15

Countercurrent EXCHANGER

PRESERVES GRADED OSMOLARITY in renal media

Answer 15

Vasa Recta

Question 16

Filtered load > Excretion rate

Answer 16

Net Reabsoprtion

Question 17

Filtered load < Excretion rate

Answer 17

Net Secretion

Question 18

Filtered Load

Answer 18

GFR x (plasma)

Question 19

Excretion rate

Answer 19

V x (urine)

Question 20

Reabsorption rate

Answer 20

Filtered Load - Excretion Rate

Question 21

Secretion Rate

Answer 21

Excretion rate - Filtered load

Question 22

Some nephrons exhibit saturation

Answer 22

Renal Threshold

Question 23

All nephrons exhibit saturation

Answer 23

Renal Transport Maximum

Question 24

Tm Curve of Glucose

Answer 24

NORMAL: filtered, 100% reabsorbed

Renal threshold: 200 mg/dL

Renal transport maximum: > 375 mg/dL

Splay: b/w 200 mg/dL - 375 mg/dL

Question 25

Tm Curve of PAH

Answer 25

NORMAL: filtered, secreted, not reabsorbed