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Physiology > Inflammation and Wound Healing > Flashcards

Inflammation and Wound Healing Flashcards

1
Q

Phases of Wound Healing

A

Hemostasis
Inflammation
Proliferation
Remodeling

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2
Q

Major INDUCER of ACUTE PHASE REACTANTS (APR)

A

IL-6

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3
Q

Involved in CACHEXIA in cancer and septic shock

A

Tumor Necrosis Factor (TNF) or Cachectin

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4
Q

INCREASED ESR

A 
most anemias
infections
inflammations
cancer (metastases, multiple myeloma)
renal disease (ESRD, nephrotic syndrome)
pregnancy
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5
Q

DECREASED ESR

A

sickle cell anemia (altered shape –> inability to form dense RBC aggregates)

polycythemia

HF

microcytosis

hypofibrinogenemia

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6
Q

Major prototypical APR

A

CRP (activates monocytes and other cytokines)

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7
Q

POSITIVE APR (Upregulated during Inflammation)

A 
Ferritin
Fibrinogen
Serum Amyloid A
Hepcidin
C reactive protein
Haptoglobin
Ceruloplasmin
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8
Q

NEGATIVE APR (Upregulated during Inflammation)

A 
Albumin
Transferrin
Transthyretin
Retinol-binding protein (RBP)
Adiponectin
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