Oxygen Transport

Question 1

Normal values of Hemoglobin

Answer 1

MEN - 13.5 - 17.5

WOMEN - 12.0 - 15.5

Question 2

Hgb + O2

Answer 2

Oxyhemoglobin

Question 3

Hgb + carbon monoxide

Answer 3

Carboxyhemoglobin

Question 4

Hgb + carbon dioxide

Answer 4

Carbaminohemoglobin

Question 5

Has the greatest reduction in oxygen delivery to the tissues

Answer 5

Carbon monoxide poisoning

normal PaO2
lower than normal arterial O2 saturation

Question 6

Oxygen binds with

Answer 6

FERROUS STATE (Fe2+)

Question 7

HbA

Answer 7

a2B2

Question 8

HbF

Answer 8

a2y2

Question 9

Oxygen binding capacity

Answer 9

maximum amount of O2 that can be bound to Hgb

measured at 100% saturation

expressed in mL O2/ gram of hemoglobin

1.34 - normal value

Question 10

Shift to the RIGHT

Answer 10

increased UNLOADING of O2 from Hgb

P50 - INCREASED

CAUSES:
CO2
Acidosis (Bohr effect)

Question 11

Shift to the LEFT

Answer 11

increased BINDING of O2 from Hgb

P50 - DECREASED

CAUSES:
Carbon Monoxide
HbF

Question 12

Hypoxemia

Answer 12

DECREASED arterial PO2

lead to HYPOXIA

A-a gradient used to differentiate b/w causes of hypoxemia

Question 13

Hypoxia

Answer 13

DECREASED tissue PO2

not always caused by hypoxemia

triggers: EPO production (through increased production of hypoxia-inducible factor 1a)