Glucagon

Question 1

The main action of glucagon is to (increase/decrease) blood glucose levels.

Answer 1

INCREASE

Question 2

Gluconeogenesis is (stimulated/inhibited) by glucagon, by decreasing fructose 2,6-bisphosphate production.

Answer 2

STIMULATED

Question 3

In the starving state, (insulin/glucagon) is released by the pancreas.

Answer 3

GLUCAGON

Question 4

The second messenger of the glucagon receptor is , which activates protein kinases and leads to enzyme phosphorylation.

Answer 4

cAMP

Question 5

Glucagon is secreted by the (alpha/beta) cells of the pancreas.

Answer 5

alpha

Question 6

Two amino acids that can stimulate the secretion of glucagon are .

Answer 6

ARGININE

ALANINE

Question 7

Glucose, fatty acids, and ketoacids are all (increased/decreased) in response to glucagon.

Answer 7

INCREASED

Question 8

The primary target tissue of glucagon is the (organ) .

Answer 8

LIVER

Question 9

Factors that INCREASE glucagon secretion

Answer 9

DECREASED blood glucose
INCREASED A.A. (arginine, alanine)
CCK (alerts alpha cells to a protein meal)
NE, Epi
Ach

Question 10

Factors that DECREASE glucagon secretion

Answer 10

INCREASED blood glucose
Insulin
Somatostatin
FA, Ketoacids

Question 11

ACTIONS of GLUCAGON

Answer 11

INCREASED blood glucose concentration

• increases glycogenolysis
• increases gluconeogenesis

INCREASED blood F.A. and ketoacid concentration
-increases lipolysis

INCREASED urea production