GI BRS

Question 1

Released from neurons in the GIT and produces smooth muscle relaxation

Answer 1

VIP

Question 2

Site of SECRETION of intrinsic factor

Answer 2

Gastric Fundus

Question 3

Vibrio cholerae causes diarrhea because it

Answer 3

cholera toxins activate adenylate cyclase and increases cAMP in intestinal crypt cells

cAMP activates Cl secretory channels and produces primary secretion of Cl w/ NA and H2 following

Question 4

CCK has some gastrin like properties because both CCK and gastrin

Answer 4

5 identical C terminal AA

Question 5

CCK INHIBITS

Answer 5

gastric emptying

Question 6

CCK STIMULATES

Answer 6

pancreatic HCO3 secretion

pancreatic enzyme secretion

Question 7

Abolishes receptive relaxation

Answer 7

vagotomy

Question 8

Site of secretion of gastrin

Answer 8

ANTRUM

FUNDUS - HCl and Ileum

Question 9

Micelle formation is necessary for the intestinal absorption of

Answer 9

vitamin D

Question 10

Changes that occur during defecation

Answer 10

relaxed internal and external anal sphincters

elevated intraabdominal pressure

Question 11

Characteristics of Saliva

Answer 11

hypotonicity
high HCO concentration
a amylase
lingual lipase

Question 12

The only GI hormone that is released in response to all categories of nutrients - fats, protein, carbohydrates (oral glucose)

Answer 12

glucose dependent insulinotropic peptide (GIP)

Question 13

Oscillating resting membrane potentials of the GI smooth muscle

Answer 13

Slow waves

Question 14

Contractile activity that is coordinated by the enteric nervous system and propels the intestinal contents forward

Answer 14

Peristalsis

circular smooth muscle must simultaneously contract behind the bolus and relax in front of the bolus

longitudinal smooth muscle relaxes (lengthens) behind the bolus an contracts (shortens) in front of the bolus

Question 15

Reversible inhibitor of H2 receptors on parietal cells and blocks H+ secretion

Also blocks the action of Ach to stimulate H+ cells

Answer 15

Cimetidine

Question 16

Blocks H+K+ATPase

Answer 16

Omeprazole

Question 17

Secreted when parietal cells are stimulated

Answer 17

HCl and IF

Question 18

A tumor of non-B cells pancreas which secretes GASTRIN

Answer 18

Zollinger Ellison syndrome (Gastrinoma)

• INCREASED H+ secretion
• PUD
• INCREASED parietal cell growth (trophic effects of gastrin)
• DECREASED absorption of lipids (inc H –> dec pH of intestinal lumen –> inactivates pancreatic lipases)

Question 19

The site of Na+bile acid cotransport

Answer 19

Ileum