RAAS Flashcards
Angiotensin II acts on the (portion of the brain) to increase thirst and water intake.
Hypothalamus
Activation of the renin-angiotensin II-aldosterone system by a decrease in mean arterial pressure will lead to a response that (increases/decreases) Na+ reabsorption, blood volume, cardiac output, and total peripheral resistance.
INCREASES
Antidiuretic hormone activation of vasopressin 2 receptors on the principal cells of the renal increases water reabsorption and maintenance of body fluid osmolarity.
Collecting Duct
Angiotensin II will stimulate Na+- H+ exchange in the renal (proximal/distal) tubules and increases the reabsorption of Na+ and HCO3- in order to increase extracellular fluid, blood volume and blood pressure.
PROXIMAL
The cells of the collecting duct are involved in potassium reabsorption and hydrogen ion secretion.
Alpha Intercalated Cells
Angiotensin II acts on the zona of the adrenal cortex to stimulate the secretion and synthesis of aldosterone.
Glomerulosa
The secretion and synthesis of aldosterone is the result of angiotensin II activation of G protein-coupled angiotensin type receptors.
1
Renin-angiotensin II-aldosterone system is (activated/deactivated) when mechanoreceptors in the afferent arterioles of the kidney senses a decrease in renal perfusion pressure.
ACTIVATED
Prorenin conversion to renin in the juxtaglomerular cells can be stimulated by a decrease in mean arterial pressure or by beta 1 (antagonists/agonists) .
Agonists
Senses decrease in NaCl delivery in DCT
Macula densa
Stimulates JG cells (Granular cells) to release RENIN
Macula Densa
Converts Liver Angiotensinogen to Angiotensin I
RENIN
Converts Angiotensin I to Angiotensin II
Lung ACE
Aldosterone effects on Kidneys
Na reabsorption
K secretion
H secretion
