Antibodies and Complement Proteins Flashcards
MOST ABUNDANT type in the serum
SMALLEST
responsible for SECONDARY IMMUNE RESPONSE
only isotype capable of crossing the PLACENTA
IgG
MOST PRODUCED ANTIBODY OVERALL (in mucous membranes) but has lower serum concentrations
Protects mucosa via IMMUNE EXCLUSION
IgA
LARGEST
Responsible for PRIMARY IMMUNE RESPONSE
Found on the SURFACE of NAIVE B CELLS
IgM
Mediates type I hypersensitivity
Associated with ALLERGIES
IgE
Found on the SURFACE of NAIVE B CELLS
Has unclear function
IgD
Targets antigen antibody complexes
Plasma proteins from the liver involved in innate immunity and inflammation
COMPLEMENT SYSTEM
opsonization
stimulate inflammation
MAC
Pathways of Complement System
Classic Pathway - triggered by IMMUNE COMPLEX
Mannose binding Lectin Pathway - triggered by lectin binding w/ mannose groups in bacteria
Alternative/Properdin Pathway - triggered by contact w/ various viruses, bacteria, fungi and tumor cells
Causes OPSONIZATION
C3b
Induces INFLAMMATION (anaphylatoxin)
C3a, C4a, C5a
Causes WBC chemotaxia
C5a
Membrane Associated Complex (MAC)
C5b-C9
Hormone like molecules that act on nearby cells (paracrine) to regulate immune responses
Secreted by lymphocytes, macrophages, endothelial cells, neurons, glial cells, other types of cells
CYTOKINES
Superfamily of >40 cytokines that attract neutrophils
CHEMOKINES
For proliferation of Hematopoietic Stem Cells
Stem Cell Factors (SCF)
ID of all host NUCLEATED cells
MHC I proteins
coupled to MUTANT or VIRAL PROTEINS (digested in proteosomes)
