Unit 3- Bordatella Flashcards
Bordatella hinzii
Commensal of fowl with rare human infection
Bordetella pertusis
Whopping cough and subgroup causing chronic non-progressive pneumonia in sheep
Bordetella bronchiseptica
Gram negative coccobacillus, bipolar stain, motile, urease positive, non fermenting, oxidase positive, catalase positive, grows on macconkey, aerobe, upper respiratory, nonsaccharolytic
Nonsaccharolytic
Non fermentative, oxidizes organic sulfur and nitrogen
Kennel Cough
B brontiseptica in dogs, pneumonia secondary to viral infection, contageous aerosol, toxins kill cilliated epithelial cells, mucous causes cough
B bronchiseptica Adherence
Preferentially adheres to epithelial cilia of the respiratory tract
Swine Atrophic Rhinitis
B bronchiseptica infection in turbinates causes jaw to shorten and twist, spread by sow, bronchopneumonia in piglet
Cat Bordetella bronchiseptica
Upper respiratory tract disease, tracheobronchitis, conjunctivitis, pneumonia, mild but can be severe and life threatening in young kitten
Bronchopneumonia
Occurs in a wide variety of animals, respiratory disease in rodents, systemic infection in immune compromised humans
B bronchiseptica Compromising Factors
Other infection, crowding, inclement weather
B bronchiseptica Virulence Factors
Fimbriae, filamentous hemagglutinin for colonization and infection of upper respiratory tract, exotoxins, LPS, motility
B bronchiseptica Exotoxins
Dermonecrotoxin, adenylate cyclase hemolysin, RTX toxin, osteotoxin, tracheal cytotoxin, T3SS
Dermonecrotoxin
Different from P multilocida toxin, causes inflammation and ciliary stasis in respiratory mucosa
B bronchiseptica Immunity
Antibodies to pili block adherence and infection, IgA mucosal immunity in dogs and colostral antibody in piglets
B bronchiseptica Vaccination
Live attenuated intranasally or subunit vaccines to pili
Bordetella avium
Gram negative coccobacillus, bipolar stain, motile, aerobe, type 2 colony causes disease, nonsaccharolytic, urea negative
B avium Disease
Fowl and humans, turkey coryza, colonize and kill ciliated epithelial cells, common in young poults
B avium Virulence Factors
Fimbriae for colonization, dermonecrotoxin, tracheal cytotoxin, hemaglutinin, LPS
B avium Predisposing Factors
Dust, overcrowding, previous respiratory infection
B avium Immunity
Mucosal IgA to prevent colonization and serum antibodies to toxins
B avium Diagnosis
Grows on macconkey, non saccharolytic, urease negative
B avium Vaccination
Vaccine given in water, subQ bacterins prevent disease, not colonization
Bordetella pertussis
Causes whooping cough in human children
Bordetella parapertussis subsp Hu
Causes less severe respiratory disease in human
Bordetella parapertussis subsp Ov
Chronic, non-progressive pneumonia in sheep, cannot infect mice