Unit 3- Bordatella

Question 1

Bordatella hinzii

Answer 1

Commensal of fowl with rare human infection

Question 2

Bordetella pertusis

Answer 2

Whopping cough and subgroup causing chronic non-progressive pneumonia in sheep

Question 3

Bordetella bronchiseptica

Answer 3

Gram negative coccobacillus, bipolar stain, motile, urease positive, non fermenting, oxidase positive, catalase positive, grows on macconkey, aerobe, upper respiratory, nonsaccharolytic

Question 4

Nonsaccharolytic

Answer 4

Non fermentative, oxidizes organic sulfur and nitrogen

Question 5

Kennel Cough

Answer 5

B brontiseptica in dogs, pneumonia secondary to viral infection, contageous aerosol, toxins kill cilliated epithelial cells, mucous causes cough

Question 6

B bronchiseptica Adherence

Answer 6

Preferentially adheres to epithelial cilia of the respiratory tract

Question 7

Swine Atrophic Rhinitis

Answer 7

B bronchiseptica infection in turbinates causes jaw to shorten and twist, spread by sow, bronchopneumonia in piglet

Question 8

Cat Bordetella bronchiseptica

Answer 8

Upper respiratory tract disease, tracheobronchitis, conjunctivitis, pneumonia, mild but can be severe and life threatening in young kitten

Question 9

Bronchopneumonia

Answer 9

Occurs in a wide variety of animals, respiratory disease in rodents, systemic infection in immune compromised humans

Question 10

B bronchiseptica Compromising Factors

Answer 10

Other infection, crowding, inclement weather

Question 11

B bronchiseptica Virulence Factors

Answer 11

Fimbriae, filamentous hemagglutinin for colonization and infection of upper respiratory tract, exotoxins, LPS, motility

Question 12

B bronchiseptica Exotoxins

Answer 12

Dermonecrotoxin, adenylate cyclase hemolysin, RTX toxin, osteotoxin, tracheal cytotoxin, T3SS

Question 13

Dermonecrotoxin

Answer 13

Different from P multilocida toxin, causes inflammation and ciliary stasis in respiratory mucosa

Question 14

B bronchiseptica Immunity

Answer 14

Antibodies to pili block adherence and infection, IgA mucosal immunity in dogs and colostral antibody in piglets

Question 15

B bronchiseptica Vaccination

Answer 15

Live attenuated intranasally or subunit vaccines to pili

Question 16

Bordetella avium

Answer 16

Gram negative coccobacillus, bipolar stain, motile, aerobe, type 2 colony causes disease, nonsaccharolytic, urea negative

Question 17

B avium Disease

Answer 17

Fowl and humans, turkey coryza, colonize and kill ciliated epithelial cells, common in young poults

Question 18

B avium Virulence Factors

Answer 18

Fimbriae for colonization, dermonecrotoxin, tracheal cytotoxin, hemaglutinin, LPS

Question 19

B avium Predisposing Factors

Answer 19

Dust, overcrowding, previous respiratory infection

Question 20

B avium Immunity

Answer 20

Mucosal IgA to prevent colonization and serum antibodies to toxins

Question 21

B avium Diagnosis

Answer 21

Grows on macconkey, non saccharolytic, urease negative

Question 22

B avium Vaccination

Answer 22

Vaccine given in water, subQ bacterins prevent disease, not colonization

Question 23

Bordetella pertussis

Answer 23

Causes whooping cough in human children

Question 24

Bordetella parapertussis subsp Hu

Answer 24

Causes less severe respiratory disease in human

Question 25

Bordetella parapertussis subsp Ov

Answer 25

Chronic, non-progressive pneumonia in sheep, cannot infect mice