Triglyceride Lowering Medications Flashcards
What is a normal level of TG’s?
Less than 150
What are the main contributors to Hypertriglyceridemia?
Metabolic syndrome, obesity, CKD, meds
What are the main contributors to Hypertriglyceridemia?
Metabolic syndrome, obesity, CKD, meds
What lifestyle modifications should be suggested?
Decrease weight, alter diet and increase exercise
What are 2 Fibrates?
Gemfibrozil
Fenofibrate
What are 2 Fibrates?
Gemfibrozil
Fenofibrate
What is the MOA for Fibrates?
(+) PPAR alpha which targets fatty acid metabolism and elevates Apo’s
What is the MOA for Fibrates?
(+) PPAR alpha which targets fatty acid metabolism and elevates Apo
Have Fibrates shown reductions in CVD mortality?
Nope - limited indications for them now
In patients with very high TG’s, what does Gemfibrozil prevent?
Acute pancreatitis
In patients with very high TG’s, what does Gemfibrozil prevent?
Acute pancreatitis
In patients with very high TG’s that are at risk for acute pancreatitis, what can prevent that?
Gemfibrozil
If Gemfibrozil is added to a statin, what adverse effect can develop?
Myopathy +/- rhabdomyolysis
Why should Gemfibrozil not be added to statins?
Can cause myopathy +/- rhabdomyolysis
Which Fibrate does NOT increase myopathy risk?
Fenofibrate
Fibrates can also cause what adverse effect?
Increased cholesterol content of bile –> gallstones
What are 2 Omega 3 fish oils?
Eicosapentoenic acid
Docosahexoenic acid
What are 2 Omega 3 fish oils?
Eicosapentoenic acid
Docosahexoenic acid
Result of Omega 3 fish oils?
Lower VLDL and cardiovascular events
Result of Omega 3 fish oils?
Lower VLDL production and cardiovascular events
