Inflammatory Myopathies

Question 1

What are the 3 types of Inflammatory Myopathies?

Answer 1

1. Dermatomyositis
2. Polymyositis
3. Inclusion Body Myositis

Question 2

Inflammatory Myopathies are autoimmune diseases. What do they present with?

Answer 2

Bilateral proximal muscle weakness and myalgias

Question 3

Inflammatory Myopathies are autoimmune diseases. What do they present with?

Answer 3

Bilateral proximal muscle weakness and myalgias

Question 4

What will be elevated and what will be normal in the serum with Inflammatory Myopathies?

Answer 4

Elevated = Creatine Kinase and Aldolase
Normal = ESR and CRP

Question 5

What will be elevated and what will be normal in the serum with Inflammatory Myopathies?

Answer 5

Elevated = Creatine Kinase and Aldolase
Normal = ESR and CRP

Question 6

Dermatomyositis

Answer 6

Weakness and skin lesions

Question 7

Weakness with certain skin lesions is what type of inflammatory myopathy?

Answer 7

Dermatomyositis

Question 8

3 common skin lesions with Dermatomyositis?

Answer 8

• Gottron’s patches
• Heliotrope rash
• V neck Erythema

Question 9

3 common skin lesions with Dermatomyositis?

Answer 9

• Gottron’s patches
• Heliotrope rash
• V neck erythema

Question 10

Gottron’s patches

Answer 10

Raised lesions over dorsal hand/fingers

Question 11

Heliotrope rash

Answer 11

Periorbital edema with purpleish eyelid discoloration

Question 12

V neck erythema

Answer 12

Poikiloderma = shawl sign

Question 13

Once Dermatomyositis is diagnosed, what should you start looking for immediately, as the patient is at an increased risk for it?

Answer 13

Occult Malignancy

Question 14

What will be seen on biopsy with Dermatomyositis?

Answer 14

Perifascicular atrophy

Perimysial and Perivascular inflammation

Question 15

What will be seen on biopsy with Dermatomyositis?

Answer 15

Perifascicular atrophy

Perimysial and Perivascular inflammation

Question 16

Polymyositis

Answer 16

Proximal muscle weakness

Question 17

Only proximal muscle weakness

Answer 17

Polymyositis

Question 18

What will be seen on biopsy with Polymyositis?

Answer 18

Endomysial inflammation

Question 19

What will be seen on biopsy with Polymyositis?

Answer 19

Endomysial inflammation

Question 20

What will be elevated (for sure) with Dermatomyositis and Polymyositis?

Answer 20

Creatine Kinase and Aldolase

Question 21

What antibody is (+) with Dermatomyositis and Polymyositis?

Answer 21

Anti JO-1

Question 22

What antibody is (+) with Dermatomyositis and Polymyositis?

Answer 22

Anti JO-1

Question 23

What is the treatment for Dermatomyositis and Polymyositis?

Answer 23

Glucocorticoids

Question 24

Inclusion Body Myositis

Answer 24

Finger flexion or Quadriceps weakness

Question 25

Finger flexion or Quadriceps weakness

Answer 25

Inclusion Body Myositis

Question 26

Creatine Kinase level with Inclusion Body Myositis?

Answer 26

NORMAL to mild elevation

Question 27

Creatine Kinase level with Inclusion Body Myositis?

Answer 27

NORMAL to mild elevation

Question 28

What will be seen on biopsy with Inclusion Body Myositis?

Answer 28

Endomysial Inflammation

RIMMED VACUOLES

Question 29

Rimmed vacuoles on biopsy are seen with?

Answer 29

Inclusion Body Myositis

Question 30

What is the treatment for Inclusion Body Myositis?

Answer 30

RESISTANT to treatment!