Indirect Adrenomimetics Flashcards
What is 1 drug that (-) reuptake of dopamine and norepinephrine?
Cocaine
Cocaine MOA
(-) reuptake of dopamine and norepinephrine
What are 2 drugs that (-) MAO?
Selegiline
Phenelzine
What are 2 drugs that (-) MAO?
Selegiline
Phenelzine
What are 3 drugs/compound that inhibit dopamine and norepinephrine re-uptake mechanisms and increase their release?
Amphetamines
Methylphenidate
Tyramine – not a drug = product of tyrosine decarboxylation
What are 3 drugs/compounds that inhibit dopamine and norepinephrine re-uptake mechanisms and increase their release?
Amphetamines
Methylphenidate
Tyramine – not a drug = product of tyrosine decarboxylation
What is 1 releasing agent of dopamine and norepinephrine AND direct agonist?
Ephedrine
What is 1 releasing agent or norepinephrine and dopamine AND direct agonist?
Ephedrine
A majority of the Indirect Adrenomimetics (besides Tyramine) are ____ and penetrate _____
Lipophilic - can penetrate BBB
= CNS effects!
How do Indirect adrenergic drugs produce their effects?
Altering neurotransmitter concentrations at target sites
Action of Tyramine?
Elevation of systolic BP and evaluation of peripheral adrenergic function
Which drug can treat chronic hypotension?
Ephedrine
Which 2 drugs can treat depression?
Phenelzine
Selegiline
MOA for Selegiline and Phenelzine and what they can treat?
(-) MAO
= Treat depression
What 2 drugs can treat Narcolepsy?
Amphetamines
Methylphenidate
MOA for Amphetamines and Methylphenidate and what they can treat?
Reverse DA and NE uptake mechanisms to increase their release
= Narcolepsy treatment
What drug can also treat ADHD?
Methylphenidate
What 2 drugs can treat obesity?
Ephedrine
Amphetamines
What are possible side effects of the Indirect Lipophilic adrenomimetics?
Insomnia, anxiety and restlessness
Hallucinations and convulsions with stroke
What are possible side effects of Indirect lipophilic adrenomimetic drugs?
Insomnia, anxiety and restlessness
Hallucinations, convulsions and stroke
