Indirect Adrenomimetics Flashcards
What is 1 drug that (-) reuptake of dopamine and norepinephrine?
Cocaine
Cocaine MOA
(-) reuptake of dopamine and norepinephrine
What are 2 drugs that (-) MAO?
Selegiline
Phenelzine
What are 2 drugs that (-) MAO?
Selegiline
Phenelzine
What are 3 drugs/compound that inhibit dopamine and norepinephrine re-uptake mechanisms and increase their release?
Amphetamines
Methylphenidate
Tyramine – not a drug = product of tyrosine decarboxylation
What are 3 drugs/compounds that inhibit dopamine and norepinephrine re-uptake mechanisms and increase their release?
Amphetamines
Methylphenidate
Tyramine – not a drug = product of tyrosine decarboxylation
What is 1 releasing agent of dopamine and norepinephrine AND direct agonist?
Ephedrine
What is 1 releasing agent or norepinephrine and dopamine AND direct agonist?
Ephedrine
A majority of the Indirect Adrenomimetics (besides Tyramine) are ____ and penetrate _____
Lipophilic - can penetrate BBB
= CNS effects!
How do Indirect adrenergic drugs produce their effects?
Altering neurotransmitter concentrations at target sites
Action of Tyramine?
Elevation of systolic BP and evaluation of peripheral adrenergic function
Which drug can treat chronic hypotension?
Ephedrine
Which 2 drugs can treat depression?
Phenelzine
Selegiline
MOA for Selegiline and Phenelzine and what they can treat?
(-) MAO
= Treat depression
What 2 drugs can treat Narcolepsy?
Amphetamines
Methylphenidate
