Systemic Vasculitides - small/variable vessels

Question 1

Vasculitides are autoimmune diseases that involve?

Answer 1

Inflammation of blood vessels that leads to ischemia and organ dysfunction

Question 2

Vasculitides are autoimmune diseases that involve?

Answer 2

Inflammation of blood vessels that leads to ischemia and organ dysfunction

Question 3

What are 3 systemic vasculitides that affect SMALL blood vessels?

Answer 3

1. IgA Vasculitis
2. Goodpasture Syndrome
3. Granulomatosis with Polyangiitis

Question 4

What are 3 systemic vasculitides that affect SMALL vessels?

Answer 4

1. IgA Vasculitis
2. Goodpasture Syndrome
3. Granulomatosis with Polyangiitis

Question 5

IgA Vasculitis affects what age group?

Answer 5

Kids

Question 6

What are the symptoms of IgA Vasculitis?

Answer 6

Palpable purpura
Arthritis
Abdominal pain and renal disease

Question 7

What are the symptoms of IgA Vasculitis?

Answer 7

Palpable Purpura
Arthritis
Abdominal pain and renal disease

Question 8

Symptoms of Goodpasture Syndrome?

Answer 8

Hematuria and Hemoptysis

Question 9

Symptoms of Goodpasture Syndrome?

Answer 9

Hematuria and Hemoptysis

Question 10

What is seen on biopsy with Goodpasture Syndrome?

Answer 10

Anti-basement membrane autoantibodies deposited

Question 11

What is seen on biopsy with Goodpasture Syndrome?

Answer 11

Anti-basement membrane autoantibodies deposited

Question 12

What is a treatment for Goodpasture Syndrome?

Answer 12

Plasmapheresis = remove antibodies

Question 13

Granulomatosis with Polyangiitis affects males or females more often?

Answer 13

Males

Question 14

General symptoms of Granulomatosis with Polyangiitis?

Answer 14

• Granulomatous inflammation
• Necrotizing vasculitis
• Glomerulonephritis
• Nasal and respiratory tract involvement
• Venous thrombotic events

Question 15

General symptoms of Granulomatosis with Polyangiitis?

Answer 15

• Granulomatous inflammation
• Necrotizing vasculitis
• Glomerulonephritis
• Nasal and respiratory tract involvement
• Venous thrombotic events

Question 16

Glomerulonephritis is seen with Granulomatosis with Polyangiitis. What will that present as?

Answer 16

Hematuria

Question 17

What are the nasal signs of Granulomatosis with Polyangiitis?

Answer 17

Saddle nose, bleeding, etc.

Question 18

What are the respiratory tract signs of Granulomatosis with Polyangiitis?

Answer 18

Cavitary lung lesions

Question 19

What will be (+) with Granulomatosis with Polyangiitis?

Answer 19

(+) ANCA

Question 20

What is seen on biopsy with Granulomatosis with Polyangiitis?

Answer 20

Granulomas

Question 21

What are 2 Systemic Vasculitides that affect VARIABLE sized blood vessels?

Answer 21

1. Eosinophilic Granulomatosis with Polyangiitis

2. Behcet Syndrome

Question 22

What are 2 Systemic Vasculitides that affect VARIABLE sized blood vessels?

Answer 22

1. Eosinophilic Granulomatosis with Polyangiitis

2. Behcet Syndrome

Question 23

Symptoms/sign of Eosinophilic Granulomatosis with Polyangiitis?

Answer 23

Asthma and Eosinophilia

Question 24

Symptoms/sign of Eosinophilic Granulomatosis with Polyangiitis?

Answer 24

Asthma and Eosinophilia

Question 25

What will be (+) with Eosinophilic Granulomatosis with Polyangiitis?

Answer 25

(+) ANCA

Question 26

What will be seen on biopsy with Eosinophilic Granulomatosis with Polyangiitis?

Answer 26

Granulomas and eosinophils

Question 27

Behcet Syndrome small vessel triad?

Answer 27

1. Recurrent mouth ulcers 2. Genital ulcers 3. Eye inflammation

Question 28

Behcet Syndrome small vessel triad?

Answer 28

1. Recurrent mouth ulcers 2. Genital ulcers 3. Eye inflammation

Question 29

Behcet Syndrome causes what in large vessels?

Answer 29

Aneurysms

Question 30

Behcet Syndrome causes what in large vessels?

Answer 30

Aneurysms

Question 31

Behcet Syndrome causes what in veins?

Answer 31

DVT

Question 32

What will arise at the site of sterile needle pricks with Behcet Syndrome?

Answer 32

Pustules

Question 33

If pustules arise with Behcet Syndrome, what occurred at that site?

Answer 33

Sterile needle prick

Question 34

What HLA is present with Behcet Syndrome?

Answer 34

HLA-B51

Question 35

HLA-B51 is present with?

Answer 35

Behcet Syndrome

Question 36

What is the treatment for all of these Systemic Vasculitides?

Answer 36

GLUCOCORTICOIDS