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2 - CPR (cardio) > Systemic Vasculitides - small/variable vessels > Flashcards

Systemic Vasculitides - small/variable vessels Flashcards

1
Q

Vasculitides are autoimmune diseases that involve?

A

Inflammation of blood vessels that leads to ischemia and organ dysfunction

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2
Q

Vasculitides are autoimmune diseases that involve?

A

Inflammation of blood vessels that leads to ischemia and organ dysfunction

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3
Q

What are 3 systemic vasculitides that affect SMALL blood vessels?

A
  1. IgA Vasculitis
  2. Goodpasture Syndrome
  3. Granulomatosis with Polyangiitis
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4
Q

What are 3 systemic vasculitides that affect SMALL vessels?

A
  1. IgA Vasculitis
  2. Goodpasture Syndrome
  3. Granulomatosis with Polyangiitis
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5
Q

IgA Vasculitis affects what age group?

A

Kids

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6
Q

What are the symptoms of IgA Vasculitis?

A

Palpable purpura
Arthritis
Abdominal pain and renal disease

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7
Q

What are the symptoms of IgA Vasculitis?

A

Palpable Purpura
Arthritis
Abdominal pain and renal disease

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8
Q

Symptoms of Goodpasture Syndrome?

A

Hematuria and Hemoptysis

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9
Q

Symptoms of Goodpasture Syndrome?

A

Hematuria and Hemoptysis

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10
Q

What is seen on biopsy with Goodpasture Syndrome?

A

Anti-basement membrane autoantibodies deposited

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11
Q

What is seen on biopsy with Goodpasture Syndrome?

A

Anti-basement membrane autoantibodies deposited

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12
Q

What is a treatment for Goodpasture Syndrome?

A

Plasmapheresis = remove antibodies

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13
Q

Granulomatosis with Polyangiitis affects males or females more often?

A

Males

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14
Q

General symptoms of Granulomatosis with Polyangiitis?

A
  • Granulomatous inflammation
  • Necrotizing vasculitis
  • Glomerulonephritis
  • Nasal and respiratory tract involvement
  • Venous thrombotic events
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15
Q

General symptoms of Granulomatosis with Polyangiitis?

A
  • Granulomatous inflammation
  • Necrotizing vasculitis
  • Glomerulonephritis
  • Nasal and respiratory tract involvement
  • Venous thrombotic events
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16
Q

Glomerulonephritis is seen with Granulomatosis with Polyangiitis. What will that present as?

A

Hematuria

17
Q

What are the nasal signs of Granulomatosis with Polyangiitis?

A

Saddle nose, bleeding, etc.

18
Q

What are the respiratory tract signs of Granulomatosis with Polyangiitis?

A

Cavitary lung lesions

19
Q

What will be (+) with Granulomatosis with Polyangiitis?

A

(+) ANCA

20
Q

What is seen on biopsy with Granulomatosis with Polyangiitis?

A

Granulomas

21
Q

What are 2 Systemic Vasculitides that affect VARIABLE sized blood vessels?

A
  1. Eosinophilic Granulomatosis with Polyangiitis

2. Behcet Syndrome

22
Q

What are 2 Systemic Vasculitides that affect VARIABLE sized blood vessels?

A
  1. Eosinophilic Granulomatosis with Polyangiitis

2. Behcet Syndrome

23
Q

Symptoms/sign of Eosinophilic Granulomatosis with Polyangiitis?

A

Asthma and Eosinophilia

24
Q

Symptoms/sign of Eosinophilic Granulomatosis with Polyangiitis?

A

Asthma and Eosinophilia

25
Q

What will be (+) with Eosinophilic Granulomatosis with Polyangiitis?

A

(+) ANCA

26
Q

What will be seen on biopsy with Eosinophilic Granulomatosis with Polyangiitis?

A

Granulomas and eosinophils

27
Q

Behcet Syndrome small vessel triad?

A
  1. Recurrent mouth ulcers
  2. Genital ulcers
  3. Eye inflammation
28
Q

Behcet Syndrome small vessel triad?

A
  1. Recurrent mouth ulcers
  2. Genital ulcers
  3. Eye inflammation
29
Q

Behcet Syndrome causes what in large vessels?

A

Aneurysms

30
Q

Behcet Syndrome causes what in large vessels?

A

Aneurysms

31
Q

Behcet Syndrome causes what in veins?

A

DVT

32
Q

What will arise at the site of sterile needle pricks with Behcet Syndrome?

A

Pustules

33
Q

If pustules arise with Behcet Syndrome, what occurred at that site?

A

Sterile needle prick

34
Q

What HLA is present with Behcet Syndrome?

A

HLA-B51

35
Q

HLA-B51 is present with?

A

Behcet Syndrome

36
Q

What is the treatment for all of these Systemic Vasculitides?

A

GLUCOCORTICOIDS

2 - CPR (cardio) (44 decks)

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