Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

2 - CPR (cardio) > ACS Drugs > Flashcards

ACS Drugs Flashcards

1
Q

What is Vasospastic Angina?

A

Episodes of vasoconstriction of coronary arteries

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the 1st choice of drugs to treat Vasospastic Angina?

A

CCBs

– ex. amlodipine or diltiazem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the 1st choice of drug to treat Vasospastic Angina?

A

CCBs

– Amlodipine or Diltiazem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

If CCBs are not available for Vasospastic Angina, what should be used?

A

Long acting Nitrates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What 3 drug classes are used for Anti-platelets with ACS?

A
  • Thromboxane A2 synthesis (-)
  • ADP receptor blockers
  • Glycoprotein receptor blockers
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What 2 drug classes are used as thrombolytics in treating ACS?

A
  • Tissue type plasminogen (+)

- Streptokinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What drug (-) Thromboxane A2 synthesis?

A

Aspirin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What directly, does Aspirin (-)?

A

Cyclooxygenase – this inhibits synthesis of Thromboxane A2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Why does Aspirin want to (-) Thromboxane A2 synthesis?

A

It causes platelet aggregation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Adverse effects of Aspirin?

A

GI bleeding and aspirin allergy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are 3 ADP (p2y12) receptor blockers?

A

Clopidogrel
Prasugrel
Ticagrelor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are 3 ADP (p2y12) receptor blockers?

A

Clopidogrel
Prasugrel
Ticagrelor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What do ADP (p2y12) receptor blockers cause to happen?

A
  • Increased adenylyl cyclase
  • Increases cAMP
    = (-) platelet activation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What do ADP (p2y12) receptor blockers cause to happen?

A
  • Increased adenylyl cyclase
  • Increases cAMP
    = (-) platelet activation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Side effect of ADP (p2y12) receptor blockers?

A

Bleeding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

With ACS, what should be started ASAP?

A

Aspirin and an ADP receptor blocker!

17
Q

With ACS, what should be started ASAP?

A

Aspirin and an ADP receptor blocker!

18
Q

What are 3 Glycoprotein receptor blockers?

A

Abciximab
Eptifibatide
Tirofoban

19
Q

What are 3 Glycoprotein receptor blockers?

A

Abciximab
Eptifibatide
Tirofoban

20
Q

MOA for Glycoprotein receptor blockers?

A

Prevent binding of ligands to GP2b/3a receptor on platelets to (-) platelet aggregation

21
Q

Adverse effect of Glycoprotein receptor blockers, especially Abciximab?

A

Bleeding

- Abciximab = Thrombocytopenia

22
Q

When are Glycoprotein receptor blockers used?

A

High risk PCIs

23
Q

MOA for tissue type plasminogen (+) and Streptokinase?

A

Activate plasminogen to plasmin = degrades fibrin

24
Q

What are 3 tissue type plasminogen (+)s?

A

Alteplase
Reteplase
Tenecteplase

25
Q

What are 3 Tissue Type Plasminogen (+)’s?

A

Alteplase
Reteplase
Tenecteplase

26
Q

Adverse effects of Streptokinase?

A

Allergic reactions and bleeding due to systemic fibrinolysis

27
Q

When are Thrombolytic agents used?

A

If PCI cannot be performed in time

28
Q

Clopidogrel resistance is due to metabolism by?

A

CYP2C19

29
Q

Clopidogrel resistance is due to metabolism by?

A

CYP2C19

2 - CPR (cardio) (44 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions