Endocarditis, Myocarditis, Pericarditis Flashcards
What are the 3 types of Endocarditis?
- Infective Endocarditis
- Non-bacterial Thrombotic Endocarditis
- Non-bacterial Verrucous Endocarditis
(–libmann Sachs)
Acute Infective Endocarditis develops on ____ heart valve endothelium
Normal
Subacute Infective Endocarditis develops on a ____ heart valve endothelium
Damaged
Non-bacterial Thrombotic and Verrucous Endocarditis are sterile platelet vegetations on cardiac valves. The patients present with?
New cardiac murmur or embolic disease
What are the main risk factors for Infective Endocarditis?
Older males
IV drug use
Poor dentition
Structural heart disease or implantable device
IV drug use leads to ____ sided Endocarditis
Right sided Endocarditis
What is the pathogenesis of Infective Endocarditis?
- Endothelial injury with platelets/fibrin adherence
- Pathogen gains access to blood
- Pathogen adheres to platelet/fibrin on valve surface
- Pathogen proliferates on endothelium
What is the pathogenesis of Infective Endocarditis?
- Endothelial injury with platelets/fibrin adherence
- Pathogen gains access to the blood
- Pathogen adheres to platelets/fibrin on valve surface
- Pathogen proliferates on endothelium
Acute Infective Endocarditis usually involves highly virulent pathogens like?
Staph. Aureus
Subacute Infective Endocarditis usually involves less virulent pathogens like?
Strep. Viridans
Enterococci
What are the clinical manifestations of Infective Endocarditis?
- Fever, malaise, night sweats, weight loss
- New cardiac murmur
- Splinter hemorrhages, janeway lesions, roth spots, osler nodes
- Vascular embolic events
What are the clinical manifestations of Infective Endocarditis?
- Fever, malaise, night sweats, weight loss
- New cardiac murmur
- Splinter hemorrhages, janeway lesions, osler nodes, roth spots on eye
- Vascular embolic events
With infective endocarditis, a new cardiac murmur can be heard. What is the usual type?
Regurgitation
What is the diagnostic measures for Infective Endocarditis?
Echocardiography (TTE) and blood cultures before antibiotics
Possible complications of Infective Endocarditis?
- Heart failure and pericarditis
- Metastatic infection/embolization
- Renal complications
What is the treatment for Infective Endocarditis?
- Infective disease consult – empiric antibiotics (vancomycin)
- Remove cardiac devices/surgery