Antiadrenergic Drugs Flashcards
What are 2 Alpha Antagonists?
Phentolamine
Phenoxybenzamine
What are 2 Alpha Antagonists?
Phentolamine
Phenoxybenzamine
Describe Phentolamine
Alpha Antagonist
- Reversible and Competitive; short acting
- Non-covalent
- Effects antagonized by high concentrations of agonists
Describe Phenoxybenzamine
Alpha Antagonist
- Irreversible and Non-competitive; longer acting
- Covalent
- Effect NOT antagonized by agonists
What are 3 Alpha 1 Antagonists only?
Prazosin
Tamulosin
Doxazosin
What are 3 Alpha 1 Antagonists only?
Prazosin
Tamulosin
Doxazosin
What are 2 Mixed Antagonists?
Labetalol
Carvedilol
What are 2 Mixed Antagonists?
Labetalol
Carvedilol
What are 3 Beta Antagonists?
Propranolol
Pindalol
Nadolol
What are 3 Beta Antagonists?
Propranolol
Pindalol
Nadolol
What are 4 Beta 1 Antagonists only?
Metoprolol
Betaxolol
Acebutolol
Atenolol
What are 4 Beta 1 Antagonists only?
Metoprolol
Betaxolol
Acebutolol
Atenolol
Labetolol, Pindolol and Acebutolol are all ____ agonists which means?
Partial agonists
= blunted sympathetic response!
Labetolol, Pindolol and Acebutolol are all ____ agonists which means?
Partial agonists
= Blunted sympathetic response
What are 2 indirect acting Antagonists?
Guanethidine
Metyrosine
What are 2 indirect acting Antagonists and their MOA?
Guanethidine - (-) NE release
Metyrosine - (-) tyrosine hydroxylase
General effects of Alpha Antagonists?
- Decreased resistance and BP
- Relaxation of smooth muscle
General effects of Alpha Antagonists?
- Decreased resistance and BP
- Relaxation of smooth muscle
Which 3 drugs can treat Pheochromocytomas?
Phentolamine
Phenoxybenzamine
Metyrosine
Which 2 drugs can treat chronic hypertension?
Prazosin
Doxazosin
Which drug can treat erectile dysfunction when combined with a vasodilator?
Phentolamine
Which drug can treat Benign Prostate Hyperplasia?
Tamulosin
Tamulosin has a greater selectivity for which Alpha receptor?
Alpha 1
Which 2 drugs are also inverse agonists?
Betaxolol
Metoprolol
