Antiadrenergic Drugs Flashcards

1
Q

What are 2 Alpha Antagonists?

A

Phentolamine

Phenoxybenzamine

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2
Q

What are 2 Alpha Antagonists?

A

Phentolamine

Phenoxybenzamine

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3
Q

Describe Phentolamine

A

Alpha Antagonist

  • Reversible and Competitive; short acting
  • Non-covalent
  • Effects antagonized by high concentrations of agonists
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4
Q

Describe Phenoxybenzamine

A

Alpha Antagonist

  • Irreversible and Non-competitive; longer acting
  • Covalent
  • Effect NOT antagonized by agonists
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5
Q

What are 3 Alpha 1 Antagonists only?

A

Prazosin
Tamulosin
Doxazosin

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6
Q

What are 3 Alpha 1 Antagonists only?

A

Prazosin
Tamulosin
Doxazosin

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7
Q

What are 2 Mixed Antagonists?

A

Labetalol

Carvedilol

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8
Q

What are 2 Mixed Antagonists?

A

Labetalol

Carvedilol

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9
Q

What are 3 Beta Antagonists?

A

Propranolol
Pindalol
Nadolol

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10
Q

What are 3 Beta Antagonists?

A

Propranolol
Pindalol
Nadolol

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11
Q

What are 4 Beta 1 Antagonists only?

A

Metoprolol
Betaxolol
Acebutolol
Atenolol

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12
Q

What are 4 Beta 1 Antagonists only?

A

Metoprolol
Betaxolol
Acebutolol
Atenolol

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13
Q

Labetolol, Pindolol and Acebutolol are all ____ agonists which means?

A

Partial agonists

= blunted sympathetic response!

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14
Q

Labetolol, Pindolol and Acebutolol are all ____ agonists which means?

A

Partial agonists

= Blunted sympathetic response

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15
Q

What are 2 indirect acting Antagonists?

A

Guanethidine

Metyrosine

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16
Q

What are 2 indirect acting Antagonists and their MOA?

A

Guanethidine - (-) NE release

Metyrosine - (-) tyrosine hydroxylase

17
Q

General effects of Alpha Antagonists?

A
  • Decreased resistance and BP

- Relaxation of smooth muscle

18
Q

General effects of Alpha Antagonists?

A
  • Decreased resistance and BP

- Relaxation of smooth muscle

19
Q

Which 3 drugs can treat Pheochromocytomas?

A

Phentolamine
Phenoxybenzamine
Metyrosine

20
Q

Which 2 drugs can treat chronic hypertension?

A

Prazosin

Doxazosin

21
Q

Which drug can treat erectile dysfunction when combined with a vasodilator?

A

Phentolamine

22
Q

Which drug can treat Benign Prostate Hyperplasia?

A

Tamulosin

23
Q

Tamulosin has a greater selectivity for which Alpha receptor?

A

Alpha 1

24
Q

Which 2 drugs are also inverse agonists?

A

Betaxolol

Metoprolol

25
Q

Which 2 drugs are also inverse agonists?

A

Betaxolol

Metoprolol

26
Q

General effects of Beta Antagonists (blockers)?

A
  • Decrease HR and contraction force and slow conduction
  • (-) renin release
  • Increase airway resistance
27
Q

General effects of Beta Antagonists (blockers)?

A
  • Decrease HR and contraction force and slow conduction
  • (-) renin release
  • Increase airway resistance
28
Q

Beta Blockers can treat?

A
HTN
Angina Pectoris
MI
Cardiac arrhythmias
Heart failure
Glaucoma
Hyperthyroidism
29
Q

Which 2 drugs can be used after MI’s?

A

Propranolol

Metoprolol

30
Q

Which 2 drugs can treat heart failure?

A

Metoprolol

Carvedilol

31
Q

Which drug can treat Glaucoma?

A

Betaxolol

32
Q

Which drug can treat hyperthyroidism?

A

Propranolol

33
Q

HTN, Angina Pectoris, cardiac arrhythmias can all be treated with?

A

Beta blockers