Antiadrenergic Drugs Flashcards
What are 2 Alpha Antagonists?
Phentolamine
Phenoxybenzamine
What are 2 Alpha Antagonists?
Phentolamine
Phenoxybenzamine
Describe Phentolamine
Alpha Antagonist
- Reversible and Competitive; short acting
- Non-covalent
- Effects antagonized by high concentrations of agonists
Describe Phenoxybenzamine
Alpha Antagonist
- Irreversible and Non-competitive; longer acting
- Covalent
- Effect NOT antagonized by agonists
What are 3 Alpha 1 Antagonists only?
Prazosin
Tamulosin
Doxazosin
What are 3 Alpha 1 Antagonists only?
Prazosin
Tamulosin
Doxazosin
What are 2 Mixed Antagonists?
Labetalol
Carvedilol
What are 2 Mixed Antagonists?
Labetalol
Carvedilol
What are 3 Beta Antagonists?
Propranolol
Pindalol
Nadolol
What are 3 Beta Antagonists?
Propranolol
Pindalol
Nadolol
What are 4 Beta 1 Antagonists only?
Metoprolol
Betaxolol
Acebutolol
Atenolol
What are 4 Beta 1 Antagonists only?
Metoprolol
Betaxolol
Acebutolol
Atenolol
Labetolol, Pindolol and Acebutolol are all ____ agonists which means?
Partial agonists
= blunted sympathetic response!
Labetolol, Pindolol and Acebutolol are all ____ agonists which means?
Partial agonists
= Blunted sympathetic response
What are 2 indirect acting Antagonists?
Guanethidine
Metyrosine
What are 2 indirect acting Antagonists and their MOA?
Guanethidine - (-) NE release
Metyrosine - (-) tyrosine hydroxylase
General effects of Alpha Antagonists?
- Decreased resistance and BP
- Relaxation of smooth muscle
General effects of Alpha Antagonists?
- Decreased resistance and BP
- Relaxation of smooth muscle
Which 3 drugs can treat Pheochromocytomas?
Phentolamine
Phenoxybenzamine
Metyrosine
Which 2 drugs can treat chronic hypertension?
Prazosin
Doxazosin
Which drug can treat erectile dysfunction when combined with a vasodilator?
Phentolamine
Which drug can treat Benign Prostate Hyperplasia?
Tamulosin
Tamulosin has a greater selectivity for which Alpha receptor?
Alpha 1
Which 2 drugs are also inverse agonists?
Betaxolol
Metoprolol
Which 2 drugs are also inverse agonists?
Betaxolol
Metoprolol
General effects of Beta Antagonists (blockers)?
- Decrease HR and contraction force and slow conduction
- (-) renin release
- Increase airway resistance
General effects of Beta Antagonists (blockers)?
- Decrease HR and contraction force and slow conduction
- (-) renin release
- Increase airway resistance
Beta Blockers can treat?
HTN Angina Pectoris MI Cardiac arrhythmias Heart failure Glaucoma Hyperthyroidism
Which 2 drugs can be used after MI’s?
Propranolol
Metoprolol
Which 2 drugs can treat heart failure?
Metoprolol
Carvedilol
Which drug can treat Glaucoma?
Betaxolol
Which drug can treat hyperthyroidism?
Propranolol
HTN, Angina Pectoris, cardiac arrhythmias can all be treated with?
Beta blockers
