Primary HTN Drugs Flashcards
What are the 4 drug classes that are primary agents for HTN?
ACEi
ARB
Thiazide Diuretics
Calcium Channel Blockers (CCB)
What are the 4 drug classes that are primary agents for HTN?
ACEi
ARB
Thiazide Diuretics
Calcium Channel Blockers (CCB)
What are the 4 ACEi?
Captopril
Lisinopril
Benazepril
Enalapril
What are the 3 ARBs?
Losartan
Valsartan
Candesartan
What are the 3 Thiazide Diuretics?
HCTZ
Chlorthalidone
Metolazone
What are the 2 types of Calcium Channel Blockers (CCB)?
Dihydropyridines
NON-dihydropyridines
What are the Dihydropyridine CCBs?
Nifedipine
Amlodipine
Felodipine
What are the Dihydropyridine CCBs?
Nifedipine
Amlodipine
Felodipine
What are the Non-dihydropyridine CCBs?
Verapamil
Diltiazem
What are the Non-dihydropyridine CCBs?
Verapamil
Diltiazem
Where do Thiazide Diuretics target?
Distal convoluted tubule
MOA for Thiazides and are they K+ sparing/losing?
(-) NaCl cotransporter
- K+ losing
Thiazide diuretics are NOT effective in patients with?
LOW GFR
What electrolyte changes/possible allergy do Thiazide diuretics cause?
Hypo-electrolytes (HYPERcalcemia)
- Sulfonamide allergy patients should not take
MOA for ACEi?
(-) ACE from converting Angiotensin 1 to Angiotensin 2
What is the half life for Captopril (ACEi)?
1.7 hours
Which ACEis have longer half lives than Captopril (1.7 hrs)?
Lisinopril
Benazepril
What are the possible toxicities seen with ACEi?
Angioedema, cough, fetal toxicity in 2/3rd trimesters especially
MOA for ARBs?
Block Angiotensin 2 receptors
What are the primary classes and agents for treating HTN?
- ACEi - captopril, lisinopril, benazepril, enalapril
- ARB - losartan, valsartan, candesartan
- Thiazide diuretics - HTCZ, chlorthalidone, metolazone
- Calcium Channel Blockers
- Dihydropyridines (amlodipine, felodipine, nifedipine)
- Non-dihydropyridines (verapamil, diltiazem)
