Adrenergic Drugs - Overview Flashcards
Adrenergic drugs control the function of the _____ nervous system
Sympathetic
What neurotransmitters do Adrenergic drugs mimic or block the action of?
Norepinephrine
Epinephrine
Dopamine
Alpha1 receptor GPCR
Gq = IP3/DAG cascade
Alpha2 receptor GPCR
Gi = (-) cAMP
Beta receptor types GPCR
Gs = (+) cAMP
Dopamine (DA) type 1 receptor GPCR
Gs = (+) cAMP
Dopamine (DA) type 2 receptor GPCR
Gi = (-) cAMP
Direct acting agonists/antagonists work by their interaction on?
The receptors
Indirect acting adrenergic drugs produce their effects by?
Altering the concentration of norepinephrine/neurotransmitter at target receptors
Generally, direct agonist acting drugs produce their effects at what location at the nerve terminals?
Post-synaptic neuron
– receptors
Generally, indirect agonist acting drugs produce their effects at what location of the nerve terminal?
Pre-synaptic neuron or synapse
Alpha 1 receptor locations and major actions (4)
Vascular smooth muscle = contraction
Pupil dilation
Prostate = contraction
Heart = increases force of contraction
Alpha 2 receptor locations and major actions (2)
Vascular smooth muscle = contraction
Fat cells = (-) lipolysis
Beta 1 receptor locations and major actions (1)
Heart = increases force and rate of contraction
– also increases renin release
Beta 2 receptor locations and major actions (3)
Respiratory, vascular and uterine smooth muscle = RELAXATION
K+ uptake in skeletal muscle
Liver = glucose production
Beta 3 receptor locations and major actions (2)
Bladder = relaxation
Fat cells = (+) lipolysis
D1 receptor action
Dilates renal blood vessels
(+) alpha 1 will cause?
Increased BP and vasoconstriction
Dilated pupil
Lowered HR
(+) alpha 2 will cause?
(-) lipolysis
(+) Beta 1 will cause?
Increased HR and contraction force and renin release
(+) Beta 2 will cause?
Bronchodilation and glucose production in liver
(+) Beta 3 will cause?
(+) lipolysis and relaxes bladder muscle
