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2 - CPR (cardio) > Oral DVT Anticoagulants > Flashcards

Oral DVT Anticoagulants Flashcards

1
Q

Vitamin K Antagonist?

A

Warfarin

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2
Q

What factors does Warfarin decrease?

A

2, 7, 9, 10, protein C and S

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3
Q

What is Warfarin used for?

A

Long term prophylaxis of thrombosis

ex. Afib, mechanical heart valves

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4
Q

Long term prophylaxis of thrombosis agent?

A

Warfarin

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5
Q

Warfarin decreases factors/proteins that are ____ dependent

A

Calcium and vitamin K

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6
Q

Warfarin is 100% ____ and excreted in?

A

Bioavailable

- Excreted in bile via liver

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7
Q

Usually, drugs are measured with their aPTT time. What is Warfarin measured with?

A

PT time

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8
Q

Adverse effects of Warfarin?

A

Bleeding, crosses placenta, many drug interactions

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9
Q

Why does Warfarin initially cause a pro-coagulant state and what can that result in?

A

Due to the short half life of protein C

= Cutaneous necrosis

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10
Q

What are the Antidote options for Warfarin?

A

Vitamin K

Prothrombin complex concentrate

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11
Q

What 3 drugs (-) factor Xa?

A

Rivaroxaban
Apixaban
Edoxaban

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12
Q

What 3 drugs (-) factor Xa?

A

Rivaroxaban
Apixaban
Edoxaban

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13
Q

Why are Xa or Thrombin (-)’s better than Warfarin?

A

Rapid onset, lower risk of bleeding, fewer drug interactions, same dose for all patients

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14
Q

Rivaroxaban or Apixaban - which is better?

A

Apixaban

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15
Q

Adverse effects/contraindications of Rivaroxaban?

A

Bleeding, avoid in pregnancy and in patients with renal or hepatic impairment
– interacts with CYP3A4

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16
Q

What is the antidote for the Xa (-)’s?

A
  • rivaroxaban, apixaban, edoxaban

= Andexanet Alfa

17
Q

What is a Thrombin (-)?

A

Dabigatran

18
Q

What is a Thrombin (-)?

A

Dabigatran

19
Q

Con and contraindication of Dabigatran?

A

Pills are unstable

- Contraindication: Mechanical heart valve patients

20
Q

What is the Antidote for Dabigatran?

A

Idarucizumab

21
Q

What is claudication?

A

Pain in the legs with exertion caused by Peripheral Artery Disease

22
Q

What drug can treat the symptoms of claudication with peripheral artery disease?

A

Cilostazol

23
Q

What drug can treat the symptoms of claudication with peripheral artery disease?

A

Cilostazol

24
Q

MOA for Cilostazol and what it treats?

A

(-) PDE3 to increase cAMP

= treats claudication from peripheral artery disease

25
Q

What drug can (-) platelet aggregation and vasodilate to treat pain in the legs from peripheral artery disease?

A

Cilostazol

26
Q

What patients should not take Cilostazol for their PAD?

A

Heart failure patients

27
Q

Peripheral artery disease is usually due to?

A

Atherosclerosis

2 - CPR (cardio) (44 decks)

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