Oral DVT Anticoagulants Flashcards
Vitamin K Antagonist?
Warfarin
What factors does Warfarin decrease?
2, 7, 9, 10, protein C and S
What is Warfarin used for?
Long term prophylaxis of thrombosis
ex. Afib, mechanical heart valves
Long term prophylaxis of thrombosis agent?
Warfarin
Warfarin decreases factors/proteins that are ____ dependent
Calcium and vitamin K
Warfarin is 100% ____ and excreted in?
Bioavailable
- Excreted in bile via liver
Usually, drugs are measured with their aPTT time. What is Warfarin measured with?
PT time
Adverse effects of Warfarin?
Bleeding, crosses placenta, many drug interactions
Why does Warfarin initially cause a pro-coagulant state and what can that result in?
Due to the short half life of protein C
= Cutaneous necrosis
What are the Antidote options for Warfarin?
Vitamin K
Prothrombin complex concentrate
What 3 drugs (-) factor Xa?
Rivaroxaban
Apixaban
Edoxaban
What 3 drugs (-) factor Xa?
Rivaroxaban
Apixaban
Edoxaban
Why are Xa or Thrombin (-)’s better than Warfarin?
Rapid onset, lower risk of bleeding, fewer drug interactions, same dose for all patients
Rivaroxaban or Apixaban - which is better?
Apixaban
Adverse effects/contraindications of Rivaroxaban?
Bleeding, avoid in pregnancy and in patients with renal or hepatic impairment
– interacts with CYP3A4
What is the antidote for the Xa (-)’s?
- rivaroxaban, apixaban, edoxaban
= Andexanet Alfa
What is a Thrombin (-)?
Dabigatran
What is a Thrombin (-)?
Dabigatran
Con and contraindication of Dabigatran?
Pills are unstable
- Contraindication: Mechanical heart valve patients
What is the Antidote for Dabigatran?
Idarucizumab
What is claudication?
Pain in the legs with exertion caused by Peripheral Artery Disease
What drug can treat the symptoms of claudication with peripheral artery disease?
Cilostazol
What drug can treat the symptoms of claudication with peripheral artery disease?
Cilostazol
MOA for Cilostazol and what it treats?
(-) PDE3 to increase cAMP
= treats claudication from peripheral artery disease
What drug can (-) platelet aggregation and vasodilate to treat pain in the legs from peripheral artery disease?
Cilostazol
What patients should not take Cilostazol for their PAD?
Heart failure patients
Peripheral artery disease is usually due to?
Atherosclerosis
