Anti-Arrhythmic Drugs - overview Flashcards

1
Q

What is the MOA for Class 1 drugs?

A

Block Na+ channels

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2
Q

What are the 3 Class 1A drugs?

A

Quinidine
Procainamide
Disopyramide

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3
Q

What are the 3 Class 1A drugs?

A

Quinidine
Procainamide
Disopyramide

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4
Q

What are the 2 Class 1B drugs?

A

Lidocaine

Mexiletine

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5
Q

What are the 2 Class 1B drugs?

A

Lidocaine

Mexiletine

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6
Q

What are the 2 Class 1C drugs?

A

Flecainide

Propafenone

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7
Q

What are the 2 Class 1C drugs?

A

Flecainide

Propafenone

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8
Q

MOA for Class 2 drugs?

A

Beta Blockers

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9
Q

What are the 2 Class 2 drugs?

A

Esmolol

Propranolol

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10
Q

What are the 2 Class 2 Beta blocking drugs?

A

Esmolol

Propranolol

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11
Q

What is the MOA for Class 3 drugs?

A

Block K+ channels

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12
Q

What are 4 Class 3 drugs?

A

Amiodarone
Sotalol
Dofetilide
Ibutilide

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13
Q

What are the 4 Class 3 drugs?

A

Amiodarone
Sotalol
Dofetilide
Ibutilide

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14
Q

What is the MOA for Class 4 drugs?

A

Calcium Channel Blockers (non-dihydropyridine)

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15
Q

What are the 2 CCBs?

A

Verapamil

Diltiazem

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16
Q

What are the 2 CCBs?

A

Verapamil

Diltiazem

17
Q

What is the Miscellaneous drug?

A

Adenosine

18
Q

What is the Miscellaneous drug?

A

Adenosine

19
Q

In what cells do FAST action potentials occur?

A

Atrial and Ventricular cardiomyocytes

Purkinje fibers

20
Q

In what cells do SLOW action potentials occur?

A

SA and AV node cells

21
Q

What are the phases of FAST action potentials?

A
0 - influx of Na+
1 - efflux of K+
2 - influx of Ca++ and K+ efflux
3 - efflux of K+
4 - Na/K ATPase and Na/Ca exchanger restore resting membrane potential
22
Q

What are the phases of the FAST action potential?

A
0 - influx of Na+
1 - efflux of K+
2 - influx of Ca++ and K+ efflux
3 - efflux of K+
4 - Na/K ATPase and Na/Ca exchanger restore resting membrane potential
23
Q

What are the phases of the SLOW action potential?

A

4 - funny current (If) and T-type calcium influx
0 - L-type calcium influx
3 - K+ efflux

24
Q

What are the phases of the SLOW action potential?

A

4 - funny current (If) and T-type calcium influx
0 - L-type calcium influx
3 - K+ efflux

25
Q

Phase 0 is the ______ phase

A

Depolarization

26
Q

Phase 0 influx ions for fast and slow action potentials?

A

FAST - Na+

SLOW - Ca++ L-type channels