Anti-Arrhythmic Drugs - overview Flashcards
What is the MOA for Class 1 drugs?
Block Na+ channels
What are the 3 Class 1A drugs?
Quinidine
Procainamide
Disopyramide
What are the 3 Class 1A drugs?
Quinidine
Procainamide
Disopyramide
What are the 2 Class 1B drugs?
Lidocaine
Mexiletine
What are the 2 Class 1B drugs?
Lidocaine
Mexiletine
What are the 2 Class 1C drugs?
Flecainide
Propafenone
What are the 2 Class 1C drugs?
Flecainide
Propafenone
MOA for Class 2 drugs?
Beta Blockers
What are the 2 Class 2 drugs?
Esmolol
Propranolol
What are the 2 Class 2 Beta blocking drugs?
Esmolol
Propranolol
What is the MOA for Class 3 drugs?
Block K+ channels
What are 4 Class 3 drugs?
Amiodarone
Sotalol
Dofetilide
Ibutilide
What are the 4 Class 3 drugs?
Amiodarone
Sotalol
Dofetilide
Ibutilide
What is the MOA for Class 4 drugs?
Calcium Channel Blockers (non-dihydropyridine)
What are the 2 CCBs?
Verapamil
Diltiazem
What are the 2 CCBs?
Verapamil
Diltiazem
What is the Miscellaneous drug?
Adenosine
What is the Miscellaneous drug?
Adenosine
In what cells do FAST action potentials occur?
Atrial and Ventricular cardiomyocytes
Purkinje fibers
In what cells do SLOW action potentials occur?
SA and AV node cells
What are the phases of FAST action potentials?
0 - influx of Na+ 1 - efflux of K+ 2 - influx of Ca++ and K+ efflux 3 - efflux of K+ 4 - Na/K ATPase and Na/Ca exchanger restore resting membrane potential
What are the phases of the FAST action potential?
0 - influx of Na+ 1 - efflux of K+ 2 - influx of Ca++ and K+ efflux 3 - efflux of K+ 4 - Na/K ATPase and Na/Ca exchanger restore resting membrane potential
What are the phases of the SLOW action potential?
4 - funny current (If) and T-type calcium influx
0 - L-type calcium influx
3 - K+ efflux
What are the phases of the SLOW action potential?
4 - funny current (If) and T-type calcium influx
0 - L-type calcium influx
3 - K+ efflux
Phase 0 is the ______ phase
Depolarization
Phase 0 influx ions for fast and slow action potentials?
FAST - Na+
SLOW - Ca++ L-type channels
