Systemic Vasculitides - medium/large vessels

Question 1

What are 3 Systemic Vasculitides that affect MEDIUM sized blood vessels?

Answer 1

1. Thromboangiitis Obliterans
2. Polyarteritis Nodosa
3. Kawasaki Disease

Question 2

What are 3 Systemic Vasculitides that affect MEDIUM sized blood vessels?

Answer 2

1. Thromboangiitis Obliterans
2. Polyarteritis Nodosa
3. Kawasaki Disease

Question 3

Who is affected by Thromboangiitis Obliterans?

Answer 3

Young males who SMOKE – must smoke

Question 4

Symptoms of Thromboangiitis Obliterans?

Answer 4

Thrombosis of distal vessels

= loss of digits, hands, feet

Question 5

What will be seen on angiography with Thromboangiitis Obliterans?

Answer 5

Corkscrew appearance

Question 6

Treatment for Thromboangiitis Obliterans?

Answer 6

Stop smoking

Question 7

What is Polyarteritis Nodosa associated with?

Answer 7

Hepatitis B Virus

Question 8

Signs of Polyarteritis Nodosa?

Answer 8

Livedo Reticularis, ulcers and gangrene

Neuropathy – foot drop

Question 9

Signs of Polyarteritis Nodosa?

Answer 9

Livedo Reticularis, ulcers and gangrene

Neuropathy – foot drop

Question 10

What is newly acquired with Polyarteritis Nodosa?

Answer 10

HTN

Question 11

Lung findings with Polyarteritis Nodosa?

Answer 11

SPARED – NO lung findings

Question 12

What will be seen on biopsy of Polyarteritis Nodosa?

Answer 12

Fibrinoid Necrosis

Question 13

What will be seen on angiography with Polyarteritis Nodosa?

Answer 13

Micro-aneurysm

Question 14

Who is affected by Kawasaki Disease?

Answer 14

Japanese males less than 5 years old

Question 15

Who is affected by Kawasaki Disease?

Answer 15

Japanese males less than 5 years old

Question 16

Symptoms of Kawasaki Disease?

Answer 16

Fever, LAD, rash and strawberry tongue

Question 17

Symptoms of Kawasaki Disease?

Answer 17

Fever, LAD, rash and strawberry tongue

Question 18

What is the usually cause of morbidity with Kawasaki Disease?

Answer 18

Coronary A. Involvement

Question 19

Treatment for Kawasaki Disease?

Answer 19

IVIG and Aspirin

Question 20

What are 2 Systemic Vasculitides that affect LARGE blood vessels?

Answer 20

1. Takayasu Arteritis

2. Giant Cell Arteritis

Question 21

What are 2 Systemic Vasculitides that affect LARGE blood vessels?

Answer 21

1. Takayasu Arteritis

2. Giant Cell Arteritis

Question 22

Takayasu Arteritis affects which large vessels?

Answer 22

Aorta and renal arteries

Question 23

Takayasu Arteritis affects the Aorta and obliterates?

Answer 23

Peripheral pulses = “pulseless disease”

Question 24

Possible aorta complications with Takayasu Arteritis?

Answer 24

Dilation, rupture, aneurysm

Question 25

When Takayasu Arteritis affects the renal arteries, what will it cause?

Answer 25

HTN | Retinopathy with copper wiring

Question 26

When Takayasu Arteritis affects the renal arteries, what will it cause?

Answer 26

HTN | Retinopathy with copper wiring

Question 27

What does Angiography show with Takayasu Arteritis?

Answer 27

Long smoother tapered stenosis

Question 28

Histo findings with Takayasu Arteritis?

Answer 28

Granuloma with some giant cells

Question 29

What vessels are affected by Giant Cell Arteritis?

Answer 29

Cranial arteries and aortic arch

Question 30

Symptoms of Giant Cell Arteritis?

Answer 30

Headache Jaw Claudication = pain while chewing Vision abnormalities

Question 31

Symptoms of Giant Cell Arteritis?

Answer 31

Headaches Jaw Claudication = pain while chewing Vision abnormalities

Question 32

What HLA is associated with Giant Cell Arteritis?

Answer 32

HLA-DR4

Question 33

What will be very elevated with Giant Cell Arteritis?

Answer 33

ESR

Question 34

What is needed to diagnose Giant Cell Arteritis and what will it show?

Answer 34

Temporal A. biopsy = Multinucleated giant cells

Question 35

What is needed to diagnose Giant Cell Arteritis and what will it show?

Answer 35

Temporal A. biopsy = multinucleated giant cells

Question 36

You should administer glucocorticoids ____ biopsy with Giant Cell Arteritis

Answer 36

BEFORE

Question 37

What will result in the patient if you do not treat them with Giant Cell Arteritis?

Answer 37

Blindness

Question 38

What frequently coexists with Giant Cell Arteritis?

Answer 38

Polymyalgia Rheumatica

Question 39

What frequently coexists with Polymyalgia Rheumatica?

Answer 39

Giant Cell Arteritis

Question 40

Polymyalgia Rheumatica

Answer 40

Subjective feelings of weakness due to muscle pain with no true objective weakness

Question 41

Polymyalgia Rheumatica

Answer 41

Subjective feeling of weakness due to muscle pain with no true objective weakness

Question 42

Stiffness, soreness and muscle pain that causes subjective feeling of weakness

Answer 42

Polymyalgia Rheumatica

Question 43

What is elevated with Polymyalgia Rheumatica?

Answer 43

ESR and CRP

Question 44

What frequently coexists with Giant Cell Arteritis?

Answer 44

Polymyalgia Rheumatica | = subjective weakness due to muscle pain with no true objective wekaness