Direct Adrenomimetics Flashcards
What are 2 Alpha Agonists?
Phenylephrine
Clonidine
What are 2 Alpha Agonists and their preferred receptor type?
Phenylephrine - Alpha 1
Clonidine - Alpha 2
What are 2 Mixed Alpha and Beta Agonists?
Norepinephrine
Epinephrine
What are 2 Mixed Alpha and Beta Agonists and which one does NOT work on Beta 2 receptor types?
Norepinephrine = LACKS beta 2 effects
Epinephrine
What are 3 Beta Agonists?
Dobutamine
Isoproterenol
Albuterol
What are 3 Beta Agonists and their preferred receptor type?
Dobutamine - Beta 1
Isoproterenol
Albuterol - Beta 2
Major effects of Epinephrine?
- Increases HR, force of contraction and conduction velocity at AV node
- Increases systolic BP
- Relaxes Bronchial muscle
- Elevates blood glucose levels
== Alpha and Beta receptor actions!
Major effects of Epinephrine?
- Increases HR, force of contraction and conduction velocity at AV node
- Increases systolic BP
- Relaxes Bronchial muscle
- Elevates blood glucose levels
== Alpha and Beta receptor actions!
Norepinephrine does NOT work on which receptor type?
Beta 2
Major effects of Norepinephrine?
- Reduces heart rate and is a vasoconstrictor
- Increases BP
What receptor does Phenylephrine stimulate and what are the effects?
Alpha 1
= Vasoconstriction with BP elevation
= Decreases HR
What receptor does Clonidine stimulate and what are the effects?
Alpha 2
= Reduction in SNS tone, BP and HR
– (-) NE release at presynaptic neuron
Isoproterenol is a ____ Agonist and what are the major effects?
Beta Agonist
= Increases cardiac output and bronchodilation
= Vasodilator and decreases arterial pressure
What receptor does Dobutamine stimulate and what are the effects?
Beta 1
= Increases heart rate and contraction force
What receptor does Albuterol stimulate and what are the effects?
Beta 2
= Bronchodilation
What drug is given for Anaphylaxis?
Epinephrine
What drugs can be given to increase BP in hypotensive emergencies?
Norepinephrine and Phenylephrine
What class of drugs can be given for long term treatment for hypertension?
Alpha 2 agonists
What 2 drugs can be given for emergency therapy for complete AV block and cardiac arrest?
Epinephrine and Isoproterenol
Adverse effects of Direct Adrenomimetics?
BP elevation
MI and heart failure
Sinus tachycardia and ventricular arrhythmias may induce sudden cardiac death
