Class 2&3 Anti-Arrhythmic Drugs Flashcards
What are the Class 2 drugs?
Esmolol
Propranolol
MOA for Class 2 drugs?
Beta blockers
Class 2 drugs affect which 3 channels in the slow conduction action potentials?
If (funny current)
T-type calcium channels
L-type calcium channels
Class 2 drugs affect on the phase 4 of action potential in nodal cells?
Decrease the slope
– funny current and T-type calcium channels
Class 2 drugs affect on the threshold of L-type calcium channels?
Increase threshold
Class 2 drugs effects on the SA node and AV node and ECG?
- Decrease HR at SA node
- Decrease AV node conductance
= Prolong PR interval on ECG
What is the half-life for Esmolol?
- Class 2 beta blocker
= 10 minutes via IV infusion
Class 2 drugs can cause what adverse effects?
Decreased cardiac output and causes bronchoconstriction
– alter lipoproteins and glucose
Class 2 drugs can cause what adverse effects?
Decreased cardiac output and causes bronchoconstriction
– alter lipoproteins and glucose
What are the Class 3 drugs?
Amiodarone
Sotalol
Dofetilide
Ibutilide
MOA for Class 3 drugs?
Block K+ channels
Class 3 drugs regulate the duration of the?
Refractory period
What ECG change will be seen with Class 3 drugs?
Prolonged QT interval, action potential and refractory period
Many of the Class 3 drugs are used in what condition?
Atrial fibrillation
Amiodarone can cause serious side effects. What are some?
AV block
Pulmonary fibrosis
Photodermatitis and eye deposits
Amiodarone can cause serious side effects. What are some?
AV block
Pulmonary fibrosis
Photodermatitis and eye deposits
What specifically do Dofetilide and Ibutilide block?
- Class 3 drugs
= Block rapid component of delayed rectifier K+ current
Which Class 3 drugs can increase your risk for Ventricular Arrhythmias?
Dofetilde
Ibutilide
