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2 - CPR (cardio) > Class 2&3 Anti-Arrhythmic Drugs > Flashcards

Class 2&3 Anti-Arrhythmic Drugs Flashcards

1
Q

What are the Class 2 drugs?

A

Esmolol

Propranolol

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2
Q

MOA for Class 2 drugs?

A

Beta blockers

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3
Q

Class 2 drugs affect which 3 channels in the slow conduction action potentials?

A

If (funny current)
T-type calcium channels
L-type calcium channels

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4
Q

Class 2 drugs affect on the phase 4 of action potential in nodal cells?

A

Decrease the slope

– funny current and T-type calcium channels

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5
Q

Class 2 drugs affect on the threshold of L-type calcium channels?

A

Increase threshold

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6
Q

Class 2 drugs effects on the SA node and AV node and ECG?

A
  • Decrease HR at SA node
  • Decrease AV node conductance
    = Prolong PR interval on ECG
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7
Q

What is the half-life for Esmolol?

A
  • Class 2 beta blocker

= 10 minutes via IV infusion

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8
Q

Class 2 drugs can cause what adverse effects?

A

Decreased cardiac output and causes bronchoconstriction

– alter lipoproteins and glucose

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9
Q

Class 2 drugs can cause what adverse effects?

A

Decreased cardiac output and causes bronchoconstriction

– alter lipoproteins and glucose

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10
Q

What are the Class 3 drugs?

A

Amiodarone
Sotalol
Dofetilide
Ibutilide

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11
Q

MOA for Class 3 drugs?

A

Block K+ channels

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12
Q

Class 3 drugs regulate the duration of the?

A

Refractory period

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13
Q

What ECG change will be seen with Class 3 drugs?

A

Prolonged QT interval, action potential and refractory period

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14
Q

Many of the Class 3 drugs are used in what condition?

A

Atrial fibrillation

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15
Q

Amiodarone can cause serious side effects. What are some?

A

AV block
Pulmonary fibrosis
Photodermatitis and eye deposits

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16
Q

Amiodarone can cause serious side effects. What are some?

A

AV block
Pulmonary fibrosis
Photodermatitis and eye deposits

17
Q

What specifically do Dofetilide and Ibutilide block?

A
  • Class 3 drugs

= Block rapid component of delayed rectifier K+ current

18
Q

Which Class 3 drugs can increase your risk for Ventricular Arrhythmias?

A

Dofetilde

Ibutilide

2 - CPR (cardio) (44 decks)

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