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Pharm Midterm 2 > TB > Flashcards

TB Flashcards

1
Q

Which TB drugs are safe in pregnancy

A

1st line

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2
Q

What are the 1st line TB drugs

A 
Isoniazid
Rifampin
Rifabutin
Rifapentine
Ethambutol
Pyrazinamide
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3
Q

What are the 2nd line TB drugs

A

Streptomycin
Ethionamide
Levofloxacin
Amikacin

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4
Q

What is the solo drug for latent infection

A

Isoniazid

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5
Q

Which 1st line TB is a P450 inhibitor

A

Isoniazid

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6
Q

Which 1st line TB is a P450 inducer

A

Rifampin

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7
Q

Which 1st line is specific for TB

A

Isoniazid

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8
Q

Which 1st line TB can cause SLE

A

Isoniazid

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9
Q

What is the DOC for TB with AIDS

A

Rifabutin

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10
Q

Which 1st line TB can cause orange body fluids

A

Rifampin

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11
Q

Which 1st line TB can cause red/green colourblindness

A

Ethambutol

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12
Q

Which 1st line can cause Non-gouty Polyarthralgia

A

Pyrazinamide

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13
Q

When is Isoniazid -static

A

Stationary phase

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14
Q

When is Isoniazid -cidal

A

Dividing

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15
Q

How does Isoniazid work

A

Activated by KatG (catalase-peroxidase)
Inhibits InhA and KasA
Decreased Mycolic Acid = No cell wall

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16
Q

What is Isoniazid an analog of

A

Pyridoxine (Supplement B6)

17
Q

What are the Isoniazid AE

A

Peripheral neuritis

Hepatotoxicity

18
Q

Does Isoniazid have cross resistance

19
Q

Isoniazid ROA

20
Q

What can the Rifampins act on

A

TB

M. kansasii

21
Q

What do the Rifampins act on clinically

A

TB, Leprosy
Meningitis prophylaxis
MRSA (with Vanco)

22
Q

How does Rifampin work

A

Binds Beta subunit of RNAP

No RNA synth

23
Q

What are the Rifampin AE

A 
Thrombocytopenia
Rash
Nephritis
Liver dysfunction
Proteinuria
GI distress
24
Q

Mechanism of Rifampin resistance

A

Point mutation in rpoB gene

Decreased permeability

25
Q

What does Ethambutol act on

A

TB

M. kansasii

26
Q

How doe Ethambutol work

A

Inhibits Arabinosyl transferase

27
Q

Ethambutol AE

A

HA, confusion
Hyperuricemia
Neuritis

28
Q

How does Ethambutol Resistance arise

A

emb mutation

Rapid resistance if used alone

29
Q

How does Pyrazinamide work

A

Hydrolyzed to pyrazinoic acid by pyrazinamidase

30
Q

Pyrazinamide AE

A

Photosensitivity
Hyperuricemia
Hepatotoxicity
Myalgia, porphyria, rash

31
Q

What do you give for life-threatening Meningitis, miliary TB or severe organ TB

A

Streptomycin

32
Q

What kind of drug is Streptomycin

A

Aminoglycoside

33
Q

Useful for drug resistant TB

A

Streptomycin

34
Q

What do you give for Isoniazid intolerant latent TB

35
Q

Congener of Isoniazid

A

Ethionamide

36
Q

Ethionamide AE

A

GI irritation

Neuro effects

37
Q

Give if TB resistant to 1st line

A

Levofloxacin

38
Q

MDR TB or Streptomycin resistant

39
Q

What do you add to resistant strain regimen

A

Fluoroquinolones

Pharm Midterm 2 (52 decks)

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