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Pharm Midterm 2 > Leprosy > Flashcards

Leprosy Flashcards

1
Q

Drugs used for Leprosy

A

Dapsone
Clofazimine
Rifampin

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2
Q

What is Leprosy

A

Granulomatous disease of peripheral nerves and mucosa of URT

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3
Q

Aside from Leprosy, what can you give Dapsone for

A

PCP

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4
Q

How does Dapsone work

A

Inhibits Dihydropteroate synthase

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5
Q

Who can have a bad reaction to Dapsone

A

Sulfa allergy

G6PD deficiency

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6
Q

Inhibits P450

A

Dapsone

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7
Q

Dapsone AE

A

GI
Fever
Hepatitis
Methemoglobinemia

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8
Q

How does Clofazimine act

A

Bind DNA inhibiting replication

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9
Q

Which Leprosy drug is a Phenazine Dye

A

Clofazimine

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10
Q

Main Clofazimine AE

A

Red/Brown skin discoloration

GI irritation - EOS enteritis

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11
Q

What do you give with Dapsone for pauci-bacillary skin lesion

A

Rifampin

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12
Q

What do you give with Rifampin for multi-bacillary skin lesion

A

Dapsone + Clofazimine

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Pharm Midterm 2 (52 decks)

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