Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm Midterm 2 > Opioids - General Info > Flashcards

Opioids - General Info Flashcards

1
Q

Where are opioid receptors located

A

CNS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the opioid receptors

A

Mu
Delta
Kappa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What 2nd messenger do opioids act throught

A

Gi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What receptor do the majority of opioids act through

A

Mu

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Where are Delta and Kappa mostly found

A

Spinal level for analgesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What effect do Kappa receptors have

A

Psychotomimesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How do opioids act

A

Close VG Ca on presynaptic and open K on postsynaptic
Decreases NTs
Inhibit ascending pain transmission
Activate descending pain-inhibitory pathways
Block inhibitory GABAergic neuron transmission

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Can tolerance be seen with opioids

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Is dependence seen with opioids

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Is addiction seen with opioids

A

Yes but not therapeutically

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the CNS effects of opioids

A 
Analgesia
Euphoria
Sedation and drowsiness
Truncal rigidity
N/V
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How do opioids cause resp depression

A

Decrease central response to CO2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What effect do opioids have on cough

A

Supression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What do opioids do to pupils

A

Miosis

Pathognomonic for toxic dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

General uses of opioids

A 
Analgesia
Acute Pulmonary Edema
Cough
Diarrhea
Shivering
Anesthesia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which opioids can you give for cough

A

Dextromethorphan
Codeine
Levopropoxyphene
Noscapine

17
Q

What opioids can you give for diarrhea

A

Loperamide

Diphenoxylate

18
Q

What opioids can you give for shivering

A

Meperidine

19
Q

How are opioids excreted

A

Converted to glucuronides and excreted by kidney

20
Q

What does 2D6 metabolize

A

Codeine
Oxycodone
Hydrocodone

21
Q

How do opioids cause hypotension

A

Peripheral vasodilation
Inhibition of baroreceptor reflex
Increased histamine release

22
Q

How do opioids cause biliary colic

A

Contraction of billiary SM

23
Q

How do opioids cause decreased renal function

A

Decreased RBF

24
Q

How do opioids cause prolong labor

A

Just does, OK

25
Q

How do opioids cause Pruritis

A

Central effects and histamine release

26
Q

What is the main opioid AE

A

Constipation

27
Q

What happens if you give a pure agonist with a weak partial agonist

A

Diminish analgesia

State of withdrawal

28
Q

Opioid + Head injury

A

CO2 retention leading to cerebral vasodilation

29
Q

Opioid + Pregnancy

A

Fetal dependence

30
Q

Opioid + Impaired pulm function

A

Acute resp failure

31
Q

Opioid + Impaired liver function

A

Decreased morphine metabolism

32
Q

Opioid + Impaired renal function

A

Longer t1/2

33
Q

Opioid + Endocrine disease

A

Prolonged/Exaggerated response

34
Q

Opioid + Sedatives/Hypnotics

A

Increase CNS depression (resp)

35
Q

Opioid + Antipsychotics

A

Increased sedation
Resp depression
Accentuate CV effects of Anti-Ms or alpha blockers

36
Q

Opioid + MAOIs

A

LIFE THREATENING

Meperidine and Tramadol

Pharm Midterm 2 (52 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions