GI drugs - Pro kinetics Flashcards

1
Q

What are the Prokinetic agents

A
  • Neostigmine
  • Bethanechol
  • Metoclopromide
  • Cisapride
  • Erythromycin
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2
Q

What stimulates Ach secretion

A

Cisapride

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3
Q

What accelerates gastric emptying and intestinal motility

A

Metoclopromide

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4
Q

What are the cholinomimetic agents

A
  • Neostigmine
  • Bethanechol
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5
Q

What is the macrolide

A

Erythromycin

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6
Q

What does Cisapride act through

A

5-HT4

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7
Q

What does Erythromycin act through

A

Motilin

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8
Q

What does Metoclopromide act through

A
  • 5-HT3, D2 blocker
  • 5-HT4 = prokinetic
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9
Q

When do you give Neostigmine

A

Pseudoobstruction in hospitalized pts

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10
Q

When do you give Bethanechol

A

Gastroparesis

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11
Q

When do you give Metoclopromide

A
  • Gastroparesis
  • Emesis in chemo
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12
Q

When do you give Cisapride

A
  • GERD
  • Constipation
  • Gastroparesis
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13
Q

What do you give for gastric emptying before endoscopy

A

Erythromycin

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14
Q

What do you give for gastroparesis

A
  • Bethanechol
  • Metoclopramide
  • Cisapride
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15
Q

How is Erythromycin administered

A

IV

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16
Q

What can cause extrapyramidal Sx

A

Metoclopromide

17
Q

What can cause arrythmia and so is avoided in pts with prolongued QT

A

Cisapride

18
Q

What do you not give in gastroparesis for fear of tolerance

A

Erythromycin

19
Q

What are the Metoclopramide AE

A
  • Sedation
  • Diarrhea
  • Galactorrhea
  • EPS