Herpes Antivirals

Question 1

What class are Herpes antivirals

Answer 1

Pur/Pyr analogs

Question 2

What are the Herpes antivirals

Answer 2

Acyclovir
Ganciclovir
Penciclovir
Famciclovir
Cidofovir
Vidarabine
Trifluridine
Foscarnet

Question 3

DOC HSV encephalitis

Answer 3

Acyclovir

Question 4

DOC retinitis and prophylaxis

Answer 4

Gancyclovir

Question 5

Immunocompromised with Keratitis, Keratoconjunctivitis

Answer 5

Vidarabine

Question 6

DOC HSV Keratoconjunctivitis and recurrent epithelial keratitis

Answer 6

Trifluridine

Question 7

CMV retinitis in immunocompromised

Answer 7

Foscarnet

Question 8

How does Acyclovir work

Answer 8

Competes with dGTP
Chain termination
Inhibit viral DNAP

Question 9

What does Acyclovir work on

Answer 9

HSV1, 2
VSV
EBV

Question 10

Which form of Acyclovir has the highest f

Answer 10

Valacyclovir

Question 11

When does Acyclovir accumulate

Answer 11

Renal failure

Question 12

How do you prevent ARF with IV Acyclovir

Answer 12

Slow infusion and hydration

Question 13

What is resistant to Acyclovir

Answer 13

CMV

Question 14

When is Gancyclovir active

Answer 14

Post phosphorylation by VIRAL kinases

Question 15

Gancyclovir AE

Answer 15

Myelosuppression

Neutropenia

Question 16

Gancyclovir contraindication

Answer 16

Pregnancy

Question 17

How is Gancyclovir resistance conferred

Answer 17

Decreased phosphorylation

Question 18

What works via DNAP inhibition and DNA chain termination

Answer 18

Gancyclovir
Cidofovir
Penciclovir
Famciclovir

Question 19

When is Cidofovir active

Answer 19

Post phosphorylation by HOST kinases

Question 20

When do you give Cidofovir

Answer 20

CMV retinitis

Gancyclovir resistant HSV

Question 21

Why do you give Probenecid with Cidofovir

Answer 21

Block renal secretion

Question 22

Cidofovir AE

Answer 22

Nephrotoxic

Question 23

How is Cidofovir Resistance conferred

Answer 23

DNAP mutation

Question 24

What is Penciclovir for

Answer 24

Cold sores

Question 25

What is Famciclovir for

Answer 25

Acute zoster | Genital herpes in immunocompromised

Question 26

Needs 3 phosphorylations to be active

Answer 26

Acyclovir

Question 27

Needs 1 phosphorylation by thymidine kinase

Answer 27

Penciclovir | Famciclovir

Question 28

What is the relationship between Penciclovir | and Famciclovir

Answer 28

Fam is prodrug

Question 29

Fam/Penciclovir AE

Answer 29

HA Nausea Diarrhea

Question 30

How does Vidarabine act

Answer 30

Triphosphate form inhibits DNA synth

Question 31

What do you give Vidarabine for

Answer 31

HSV CMV VZV

Question 32

Vidarabine AE

Answer 32

Superficial punctate keratitis Pain Photophobia

Question 33

Acyclovir resistant HSV, CMV

Answer 33

Foscarnet

Question 34

Gancyclovir resistant CMV, VZV

Answer 34

Foscarnet

Question 35

How does Trifluridane work

Answer 35

Triphosphate form incorporates into DNA causing fragmentation

Question 36

Opthalmic ointments

Answer 36

Vidarabine | Trifluridine

Question 37

Trifluridine AE

Answer 37

Irritation | Palpebral edema

Question 38

Foscarnet AE

Answer 38

Nephrotoxic Electrolyte disturbances Anemia CNS

Question 39

How is Foscarnet resistance conferred

Answer 39

Point mut in polymerase

Question 40

Does Foscarnet require phosphorylation

Answer 40

NO

Question 41

What is Foscarnet an analog of

Answer 41

Pyrophosphate

Question 42

What does Foscarnet do

Answer 42

Inhibit binding in viral DNAP