NNRTIs Flashcards
1
Q
What are NNRTIs
A
Highly selective, non-competitive inhibitors of HIV-I RT
2
Q
Do NNRTIs require phosphorylation
A
No
3
Q
NNRTI cross resistance
A
Between NNRTIs, NOT NRTIs
4
Q
Main NNRTI AE
A
Skin Rash - Steven Johnson
5
Q
Which NNRTI are 3A4 inducers
A
Nevirapine
Etravirine
Efavirenz
6
Q
Which NNRTI is a 3A4 inhibitor
A
Delavirdine
7
Q
Which NNRTI is a 2C9, 2C19 inhibitor
A
Etravirine
8
Q
What metabolizes Nevirapine
A
3A4
2D6
9
Q
What are the NNRTIs
A
Nevirapine
Etravirine
Efavirenz
Delavirdine
10
Q
Main Nevirapine AE
A
Hepatotoxicity
11
Q
When do you not give Nevirapine
A
Women CD4 > 250
Men CD4 > 400
12
Q
How does Nevirapine/Delavirdine resistance arise
A
Mutation at target site
13
Q
What does non-linear kinetics mean
A
t1/2 increases with dose
14
Q
Which NNRTI has non-linear kinetics
A
Delavirdine
15
Q
Where is Delavirdine excreted
A
Kidneys
