Antifungals - General and Pneumocystis Flashcards
1
Q
Alter cell membrane permeability
A
Polyenes
Azoles
Allylamines
2
Q
Block nucleic acid synthesis
A
Flucytosine
3
Q
Disrupt MT function
A
Griseofulvin
4
Q
Disrupt cell wall
A
Echinocandins
5
Q
Systemic drugs for systemic and superficial mycoses
A
Amphotericin B
Flucytosine
Azoles
Echinocandins
6
Q
Systemic drugs for superficial mycoses
A
Griseofulvin
Terbinafine
Keto/Fluco/Itraconazole
7
Q
Topical drugs for superficial mycoses
A
Nystatin
Amphoteracin B
Imidazoles
Terbinafine
8
Q
Why doesn’t PCP respond to antifungals
A
No ergosterol
9
Q
What is the most common opportunist infection
A
PCP
10
Q
PCP Sx
A
Fever
Dyspnea
Cough
11
Q
DOC PCP
A
Cotrimoxazole
12
Q
Alternative PCP therapies
A
Clindamycin + Primaquine
Dapsone + TMP
Atorvaquone
Pentamidine
13
Q
When should you add prednisone to PCP Tx regimen
A
Moderate to severe disease
Indicated by low PO2
