Anticancer - Misc Flashcards
What are the Misc Anticancer agents
Hydroxyurea
L-Asparaginase
Arsenic trioxide
Interferon
Where does Hydroxyurea work
S
Urea analog
Hydroxyurea
What does Hydroxyurea do
Inhibit ribonucleotide reductase
Decrease DNA synth
When do you give Hydroxyurea
Melanoma
CML
Increase HbF in Sickle Cell
What are the Hydroxyurea AE
Reversible Leukopenia
GI tox
Mild derm changes
When does L-Asparaginase act
G1
How does L-Asparaginase work
Hydrolyze Asparagine to Aspartate and Ammonia
Inhibition of protein synthesis
When do you give L-Asparaginase
Acute Leukemia in children
What are the main L-Asparaginase AE
Hemorrhage
Pancreatitis
What are the other L-Asparaginase AE
HS
Hyperglycemia
HA
When do you give Arsenic trioxide
AML that’s PML-, RARalpha+
What does Arsenic trioxide do
Induce differentiation and apoptosis of leukemic cells
What are the Arsenic trioxide AE
HA
Arrhythmia
Fluid retention
Increased risk for skin CA
What does Interferon do
Stimulate NK by increasing HLA expression on tumor
