Anticancer - Hormonal Agents Flashcards
What are the Glucorticoids
Dexamethasone
Hydrocortisone
Prednisone
Prednisolone
What are the Estrogens
Diethylstilbestrol
Ethinyl estradiol
What are the Estrogen Inhibitors
Tamoxifen Raloxifen Aminoglutethimide Anastrazole Letrozole Exemestane Formestane
What are the Progestins
Hydroxyprogesterone
Megestrol
What are the Androgens
Fluoxymesterone
Testosterone
What are the Anti-androgens
Leuprolide
Goserelin
Flutamide
Used in palliative care to improve feeling of well-being
Glucocorticoids
When are the Estrogens contraindicated
Breast CA
Ovarian CA
How do Glucocorticoids and Estrogens work
Bind cytoplasmic receptor
Modulate gene expression
When are Glucocorticoids given
ALL Hodgkin's Lymphoma Edema in spinal cord compression Autoimmune anemia Thrombocytopenia
What are the Glucocorticoid AE
Immunosuppression Poor wound healing Osteoporosis Hyperglycemia Mood swings
What are Estrogens given for
Prostate CA
What are the Estrogen AE
Thromboembolism Migraine Cholestasis Mood changes Gynecomastia and Impotence
Where does Tamoxifen work
Antagonist at Breast
Agonist on Endometrium and Bone
Where does Raloxifen work
Antagonist at Breast, Endometrium and Bone
What do Tamoxifen and Raloxifen inhibit
Estrogen receptor
When do you give Tamoxifen
Metastatic Breast CA
Decrease incidence of Breast CA in high risk women
What are the AE of Estrogen Receptor blockers
Hot flush
Thrombosis
Fluid retention
Increased risk of Endometrial CA
What are the Aromatase inhibitors
Aminoglutethimide Anastrazole Letrozole Exemestane Formestane
What else does Aminoglutethimide block
Adrenal and Extra-adrenal steroid synthesis
When do you give Aminoglutethimide
ER+ Metastatic Breast CA
Which Aromatase Inhibitors are Steroids
Aminoglutethimide
Exemestane
Formestane
Which Aromatase Inhibitors are Non-steroidal
Anastrazole
Letrozole
What do you give for ER+ Metastatic Breast CA that is resistant to Tamoxifen
Exemestane
Formestane
Anastrazole
Letrozole
What causes a hot flush and headache
Exemestane
Formestane
What causes Mood changes, acne and hair growth
Anastrazole
Letrozole
Which of the Aromatase inhibitors are Irreversible
Anastrazole
Letrozole
Palliative care to improve appetite and feeling of well-being in terminal pts
Hydroxyprogesterone
Megestrol
Fluoxymesterone
Testosterone
What do you give Progestins for
Endometrial CA
What are the Progestin AE
Weight gain Depression Edema Acne Decreased HDL
A continuous dose can cause medical castration (Decreased FSH/LH)
Leuprolide
Goserelin
GnRH analogs (supress steroidogenesis)
Leuprolide
Goserelin
When do you give GnRH analogs
Prostate CA
Uterine fibroids
What are the GnRH analog AE
Initial flare up of androgen dependent CA
Decrease bone mass
Hot flush
Impotence and Gynecomastia
What do you give GnRH analogs with
Flutamide
What does Flutamide do
Inhibit initial tumor flare-up
How does Flutamide work
Inhibit androgen uptake/binding to target tissue
When do you give Flutamide
Prostate CA
