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Pharm Midterm 2 > Anticancer - Hormonal Agents > Flashcards

Anticancer - Hormonal Agents Flashcards

1
Q

What are the Glucorticoids

A

Dexamethasone
Hydrocortisone
Prednisone
Prednisolone

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2
Q

What are the Estrogens

A

Diethylstilbestrol

Ethinyl estradiol

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3
Q

What are the Estrogen Inhibitors

A 
Tamoxifen
Raloxifen
Aminoglutethimide
Anastrazole
Letrozole
Exemestane
Formestane
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4
Q

What are the Progestins

A

Hydroxyprogesterone

Megestrol

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5
Q

What are the Androgens

A

Fluoxymesterone

Testosterone

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6
Q

What are the Anti-androgens

A

Leuprolide
Goserelin
Flutamide

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7
Q

Used in palliative care to improve feeling of well-being

A

Glucocorticoids

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8
Q

When are the Estrogens contraindicated

A

Breast CA

Ovarian CA

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9
Q

How do Glucocorticoids and Estrogens work

A

Bind cytoplasmic receptor

Modulate gene expression

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10
Q

When are Glucocorticoids given

A 
ALL
Hodgkin's Lymphoma
Edema in spinal cord compression
Autoimmune anemia
Thrombocytopenia
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11
Q

What are the Glucocorticoid AE

A 
Immunosuppression
Poor wound healing
Osteoporosis
Hyperglycemia
Mood swings
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12
Q

What are Estrogens given for

A

Prostate CA

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13
Q

What are the Estrogen AE

A 
Thromboembolism
Migraine
Cholestasis
Mood changes
Gynecomastia and Impotence
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14
Q

Where does Tamoxifen work

A

Antagonist at Breast

Agonist on Endometrium and Bone

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15
Q

Where does Raloxifen work

A

Antagonist at Breast, Endometrium and Bone

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16
Q

What do Tamoxifen and Raloxifen inhibit

A

Estrogen receptor

17
Q

When do you give Tamoxifen

A

Metastatic Breast CA

Decrease incidence of Breast CA in high risk women

18
Q

What are the AE of Estrogen Receptor blockers

A

Hot flush
Thrombosis
Fluid retention
Increased risk of Endometrial CA

19
Q

What are the Aromatase inhibitors

A 
Aminoglutethimide
Anastrazole
Letrozole
Exemestane
Formestane
20
Q

What else does Aminoglutethimide block

A

Adrenal and Extra-adrenal steroid synthesis

21
Q

When do you give Aminoglutethimide

A

ER+ Metastatic Breast CA

22
Q

Which Aromatase Inhibitors are Steroids

A

Aminoglutethimide
Exemestane
Formestane

23
Q

Which Aromatase Inhibitors are Non-steroidal

A

Anastrazole

Letrozole

24
Q

What do you give for ER+ Metastatic Breast CA that is resistant to Tamoxifen

A

Exemestane
Formestane
Anastrazole
Letrozole

25
Q

What causes a hot flush and headache

A

Exemestane

Formestane

26
Q

What causes Mood changes, acne and hair growth

A

Anastrazole

Letrozole

27
Q

Which of the Aromatase inhibitors are Irreversible

A

Anastrazole

Letrozole

28
Q

Palliative care to improve appetite and feeling of well-being in terminal pts

A

Hydroxyprogesterone
Megestrol
Fluoxymesterone
Testosterone

29
Q

What do you give Progestins for

A

Endometrial CA

30
Q

What are the Progestin AE

A 
Weight gain
Depression
Edema
Acne
Decreased HDL
31
Q

A continuous dose can cause medical castration (Decreased FSH/LH)

A

Leuprolide

Goserelin

32
Q

GnRH analogs (supress steroidogenesis)

A

Leuprolide

Goserelin

33
Q

When do you give GnRH analogs

A

Prostate CA

Uterine fibroids

34
Q

What are the GnRH analog AE

A

Initial flare up of androgen dependent CA
Decrease bone mass
Hot flush
Impotence and Gynecomastia

35
Q

What do you give GnRH analogs with

A

Flutamide

36
Q

What does Flutamide do

A

Inhibit initial tumor flare-up

37
Q

How does Flutamide work

A

Inhibit androgen uptake/binding to target tissue

38
Q

When do you give Flutamide

A

Prostate CA

Pharm Midterm 2 (52 decks)

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